西安交通大学学报（医学版）2017，Vol.38Issue(3)：343-347,5.DOI:10.7652/jdyxb201703005
陕西省育龄妇女围孕期服用叶酸与产儿先天性心脏病的关系
Association between congenital heart disease and folic acid supplementation during periconceptional period among women of childbearing age in Shaanxi
摘要
Abstract
Objective To explore the association between folic acid supplementation during periconcerptional period and congenital heart disease in newborns to provide scientific evidence for making intervening measures.Methods Using stratified random cluster sampling,a total of 30 counties were sampled from Shaanxi Province.A questionnaire survey was conducted among childbearing-aged women pregnant between January 2010 and November 2013.All of the included women had definite pregnancy outcomes and had signed the consent form.Logistic regression was performed to investigate the association between folic acid supplementation during pregnancy and congenital heart disease in newborns.Results In total,28 354 questionnaires were available for analysis.The overall prevalence of congenital heart disease among live-birth neonates in the present study was 7.3‰.The percentage of childbearing-age women who had taken folic acid supplementation during pregnancy was 64.4％,while only 17.2％ of them took folic acid according to the specification.Taking folic acid regularly during pregnancy was associated with a lower risk of congenital heart disease among the newborns (OR 0.502,95％ CI:0.279 0.902).The multiple-factor analysis results also showed that taking folic acid regularly during periconcerptional period could reduce the risk of congenital heart disease (adjusted OR=0.512,P=0.046) when we controlled the family background factors,mother factors and exposure risk factors during pregnancy.However,no association was found between irregularly taking folic acid during periconcerptional period and the risk of congenital heart disease.Conclusion Taking folic acid according to the specification during periconcerptional period (taking folic acid during 3 months before pregnancy to 3 months after pregnancy with a daily dose of 0.4mg for more than 90 days) may prevent congenital heart disease of newborns.关键词
先天性心脏病/叶酸服用/Logistic回归分析Key words
congenital heart disease/folic acid supplementation/logistic regression analysis分类
医药卫生引用本文复制引用
袁淑怡,颜虹,曾令霞,李强,王全丽,赵亚玲,党少农..陕西省育龄妇女围孕期服用叶酸与产儿先天性心脏病的关系[J].西安交通大学学报（医学版）,2017,38(3):343-347,5.基金项目
陕西省卫计委出生缺陷防治课题(No.sxwsjswzfcght2016-013)和国家自然科学基金资助(No.81230016)Supported by the Birth Defect Control and Prevention Project of Shaanxi Commission of Health and Family Planning (No.sxwsjswzfcght2016-013) and the National Natural Science Foundation of China (No.81230016) （No.sxwsjswzfcght2016-013）
