西安交通大学学报（医学版）2017，Vol.38Issue(3)：366-370,5.DOI:10.7652/jdyxb201703009
西安市2010-2015年空气污染对出生缺陷影响的时间序列分析
Time-series analysis of air pollution and birth defects during 2010 to 2015 in Xi'an
摘要
Abstract
Objective To study the effects of air pollution including sulphur dioxide (SO2),nitrogen dioxide (NO2) and PM10 in Xi'an on birth defects.Methods We collected the birth defects data from Xi'an Maternal and Child Health Hospital,meteorological data from Xi'an Bureau of Meteorology,and the air pollution data from Xi'an Environment Monitoring Station from 2010 to 2015.Generalized additive model (GAM) was used to explore the relationship between air pollution and birth defects after adjusting the effects of long-term and seasonal trend,temperature,and relative humidity.Results The monthly average birth defects were 89 cases;the monthly average concentration of SO2,NO2 and PM10 was 34.05 μg/m3,45.13 μg/m3,and 96.77 μg/m3,respectively.In the GAM,the monthly average temperature was 13.57 ℃ and the relative humidity was 63.20％.The three kinds of air pollutants all had a certain lag effect in 10 months,which reached the maximum.With an increase of concentration by 10 μg/m3 in three air pollutants,the relative risks and confidence interval of SO2,NO2,and PM10 were 1.060 (1.023-1.097),1.033 (1.014-1.052) and 1.018 (1.007-1.029),with significant differences (P＜0.05).Conclusion Exposure to SO2,NO2,and PM10 may be associated with the risk of birth defects.关键词
空气污染/二氧化硫(SO2)/二氧化氮(NO2)/PM10/出生缺陷/时间序列分析Key words
air pollution/SO2/NO2/PM10/birth defect/time-series analysis分类
医药卫生引用本文复制引用
王玲玲,党少农,相晓妹,宋辉,董敏,张水平,米自冰,章琦,张丽,颜虹..西安市2010-2015年空气污染对出生缺陷影响的时间序列分析[J].西安交通大学学报（医学版）,2017,38(3):366-370,5.基金项目
陕西省卫计委出生缺陷防治课题(No.sxwsjswzfcght2016-013)和国家自然科学基金资助项目(No.81230016)Supported by the Birth Defect Control and Prevention Project of Shaanxi Commission of Health and Family Planning (No.sxwsjswzfcght2016-013) and the National Natural Science Foundation of China (No.81230016) （No.sxwsjswzfcght2016-013）
