西安交通大学学报（医学版）2017，Vol.38Issue(3)：397-401,5.DOI:10.7652/jdyxb201703015
阿托伐他汀的不同用药方式对心肌缺血再灌注损伤的影响及机制
Effects of different administrations of atorvastatin on myocardial ischemia/reperfusion in rats
摘要
Abstract
Objective To study the effects and mechanism of different administrations of atorvastatin on myocardial ischemia/reperfusion (MI/R) in rats.Methods A total of 160 male SD rats were randomly divided into five groups:sham group,MI/R group,atorvastatin of conventional dose (MI/R + N) group,atorvastatin of preoperative signal loading dose (MI/R+SL) group,and atorvastatin of preoperative continuous loading dose (MI/ R+ML) group.MI/R model was established in the rats.Myocardial infarction size was detected by Evans blue/ TTC staining.The activity of ATPase of cardiac muscle and the levels of serum IL-6 and TNF-α were detected by ELISA.The level of LVEF％ was detected by small animal ultrasound.Results Compared with MI/R+N group,MI/R+ SL and MI/R+ ML groups had significantly smaller myocardial infarction size (P＜0.05),higher activity of ATPase (P＜0.05),lower levels of serum IL-6 andTNF-α (P＜0.05),and more advancedLVEF％ (P＜0.05).However,MI/R+SL group and MI/R+ML group did not differ significantly in the above-mentioned parameters.Conclusion Atorvastatin of loading dose might alleviate MI/R injury by improving ATP metabolism of cardiac muscle and reducing abnormal expressions of inflammation factors.Meanwhile,the administration of preoperative continuous loading dose and preoperative signal loading dose of atorvastatin may not differ in protecting against MI/R injury.关键词
阿托伐他汀/心肌缺血/再灌注/ATP酶/大鼠/白细胞介素-6(IL-6)/肿瘤坏死因子-α(TNF-α)/心肌梗死Key words
atorvastatin/myocardial ischemia/reperfusion/ATPase/rat/IL-6/TNF-α/myocardial infarction分类
医药卫生引用本文复制引用
戴一,苏庚荀,白晓军,乌宇亮,牟建军..阿托伐他汀的不同用药方式对心肌缺血再灌注损伤的影响及机制[J].西安交通大学学报（医学版）,2017,38(3):397-401,5.基金项目
国家自然科学基金项目资助(No.81370357 （）
No.81570381)Supported by the National Natural Science Foundation of China (No.81370357 and No.81570381) （No.81370357 and No.81570381）
