西北国防医学杂志2017，Vol.38Issue(6)：351-356,6.DOI:10.16021/j.cnki.1007-8622.2017.06.001
化疗联合DC-CIK细胞免疫治疗对晚期结直肠癌的临床疗效及免疫功能的影响
Effect of chemotherapy combined with DC-CIK cell immunotherapy on advanced colorectal cancer and immune function
摘要
Abstract
Objective:To investigate the clinical effect of chemotherapy combined with DC -CIK immune therapy on patients with advanced colorectal cancer.Methods:A total of 68 patients with advanced colorectal cancer admitted from April 2013 to January 2016 were randomly divided into study group (n =34,DC-CIK cells combined with FOLFOX scheme chemotherapy) and control group (n =34,FOLFOX scheme chemotherapy only).The immune function,quality of life,clinical efficacy and safety were evaluated and compared between the two groups.Results:After treatment,positive cell rates of CD3 +,CD3 +/CD4 + T lymphocytes,CD3 +/CD8 + T lymphocytes,NK cells,the contents of IFN-γand IL-2 were decreased significantly (P ＜ 0.05),while the content of IL-6 increased significantly in the control group (P＜0.05);in contrast,after treatment,the positive cell rates of CD3+,CD3+/ CD4+ T lymphocytes,CD3+/CD8 + T lymphocytes,NK cells,CIK cells and the contents of IFN-γ and IL-2 were increased significantly in the study group (P ＜ 0.05),which was significantly higher than those in the control group (P ＜0.05).After treatment,the quality of life improvement rate,disease response rate,disease control rate in the study group were 82.35％,58.82％,82.35％,which were significantly higher than those in the control group (P＜ 0.05).The incidence of adverse reactions in the study group was significantly less than that in the control group.Conclusion:DC-CIK cell immunotherapy combined with chemotherapy can significantly improve the clinical efficacy,immune function and life quality of patients with advanced colorectal cancer.关键词
结直肠癌/细胞因子诱导的杀伤细胞/树突状细胞/免疫治疗Key words
colorectal cancer/cytokine induced killer cells/dendritic cells/immune therapy分类
医药卫生引用本文复制引用
王晓辉,张俊,惠玲,罗芸..化疗联合DC-CIK细胞免疫治疗对晚期结直肠癌的临床疗效及免疫功能的影响[J].西北国防医学杂志,2017,38(6):351-356,6.基金项目
甘肃省科技重大专项资助项目(1302FKDA039) （1302FKDA039）
