西北国防医学杂志2017，Vol.38Issue(6)：361-364,4.DOI:10.16021/j.cnki.1007-8622.2017.06.003
塞来昔布对大鼠氧诱导视网膜病变模型中新生血管的形态学影响
Effects of celecoxib on morphological change of neovascularization in rat model of oxygen induced retinopathy
任兵 1李鹏 2罗英 1高晓唯1
作者信息
- 1. 解放军474医院全军眼科中心,新疆乌鲁木齐 830013
- 2. 石河子大学医学院
- 折叠
摘要
Abstract
Objective:To investigate the effects of celecoxib on morphological change of neovascularization in oxygen induced retinopathy (OIR),through intravitreal injection of celecoxib in rat model of OIR.Methods:Forty-eight 7 day old SD rats were randomly divided into 3 groups:control group,ROP group,ROP+ 20 μg celecoxib group.Control group received normal partial oxygen pressur,ROP group,ROP+20 μg celecoxib group were established the OIR model.The neonatal rats were given intravitreal injections of DMSO and the corresponding doses of celecoxib on the 12th day after birth.The rats were sacrificed on the 17th after birth,HE staining were employed to count the vascular endothelial cells which were breakthrough within the internal limiting membrane of retina.Results:HE staining showed that the number of the endothelial cells in the retina was (0.44 ± 0.18)、(30.60 ± 5.36)、(10.13 ± 1.93) in three groups,there were significant differences between the three groups (all P ＜0.05),after treatment with celecoxib,breakthrough of the internal limiting membrane of the vascular endothelial cell nucleus was significantly reduced,and positively correlated with the dose.Conclusion:Celecoxib can inhibit the OIR model of rat retinalangiogenesis.关键词
视网膜病变/塞来昔布/新生血管Key words
retinopathy/celecoxib/neovascularization分类
医药卫生引用本文复制引用
任兵,李鹏,罗英,高晓唯..塞来昔布对大鼠氧诱导视网膜病变模型中新生血管的形态学影响[J].西北国防医学杂志,2017,38(6):361-364,4.
