现代妇产科进展2017，Vol.26Issue(7)：493-496,4.DOI:10.13283/j.cnki.xdfckjz.2017.07.003
腹腔热灌注联合多西他赛、奥沙利铂静脉化疗治疗晚期卵巢癌疗效观察
Effect observation of hyperthermic intraperitoneal chemotherapy combined intravenous chemotherapy with docetaxel and oxaliplatin in patients with advanced ovarian cancer
摘要
Abstract
Objective:To evaluate the effect of hyperthermic intraperitoneal chemotherapy combined intravenous chemotherapy with oxaliplatin and docetaxel after cytoreductive surgery (CRS) in patients with advanced ovarian cancer.Methods:A total of 42 cases of advanced (stage III~IV) ovarian cancer patients confirmed by clinical diagnosis between Jan.2011 and Dec.2014 were included in the study.The patients were divided into the study group(n=21 cases) and control groups (n=21 cases).The study group was treated with docetaxel and oxaliplatin venous chemotherapy and hyperthermic intraperitoneal chemotherapy after CRS.While the control group was treated with paclitaxel and carboplatin venous chemotherapy after CRS.Clinical treatment results for curative effects,remission rate of tumor,controlled rate of ascites,quality of life,toxicity and adverse reactions and PFS were compared and analyzed after treatment.Results:The total remission rate of tumor of the study is better than control group,but the difference was not statistically significant (P>0.05).The controlled rate of ascites,quality of life and PFS in the study group were all better than patients in the control group (P<0.05).The difference of the rate of toxicity and adverse reactions between the study group and the control group was not statistically significant (P>0.05).Conclusion:Applying the combination of docetaxel and oxaliplatin venous chemotherapy and hyperthermic intraperitoneal chemotherapy to treat advanced ovarian cancer after CRS can improve the curative effects,remission rate of tumor,controlled rate of ascites,quality of life,PFS and with little toxicity and adverse reactions.关键词
晚期卵巢癌/腹腔热灌注/多西他赛/奥沙利铂/静脉化疗/联合治疗Key words
Advanced ovarian cancer/Hyperthermic intraperitoneal chemotherapy/Oxaliplatin/Docetaxel/Intravenous chemotherapy/Combination therapy分类
医药卫生引用本文复制引用
李楠,杨亮,孙亚楠,吴小华,韩金柱,陈素琴,杜星星,于文娜..腹腔热灌注联合多西他赛、奥沙利铂静脉化疗治疗晚期卵巢癌疗效观察[J].现代妇产科进展,2017,26(7):493-496,4.基金项目
本课题为河北省科技计划项目(No:152777220) （No:152777220）
