中国组织工程研究2017，Vol.21Issue(20)：3190-3195,6.DOI:10.3969/j.issn.2095-4344.2017.20.013
股骨延迟愈合外固定模型兔的建立与评估
Establishment and evaluation of a rabbit model of femoral delayed union using external fixation
张志天 1王淑民 2赵景新 3张猛3
作者信息
- 1. 河北省承德县三沟中心卫生院骨外科,河北省承德市 067000
- 2. 河北省承德县妇幼保健计划生育服务中心,河北省承德市 067000
- 3. 承德医学院附属医院创伤骨科,河北省承德市 067000
- 折叠
摘要
Abstract
BACKGROUND: Mechanisms related to bone fracture and nonunion have been clarified, but the healing time and treatment strategy of delayed union remain controversial. OBJECTIVE: To establish a reliable model of femoral delayed union using external fixation in the New Zealand white rabbit. METHODS: Seventy-two New Zealand white rabbits were randomized to three groups. After removal of 10-mm femoral middle bone cortex with internal and external periosteum and bone marrow, a uniplanar external fixator was used. There was a 1 mm gap between broken ends (group A), and the broken ends were sealed by bone wax (group B). For controls, only bone cortex was cut and then fixed to contact the broken ends. The gross, radiological and histological observations were performed to observe the bone healing at 4, 8 and 12 weeks after modeling. RESULTS AND CONCLUSION: The control group achieved bone healing at the 4th week, which was considered as the normal time of bone healing. The groups A and B achieved healing at the 12th week, which was remarkably longer than that in the control group. The rabbit femoral delayed union model showed the typical X-ray imaging and pathological features of delayed union. Our results suggest that the model is reasonable and reliable, which can provide reference for clinical research.关键词
组织构建/骨组织工程/模型,动物/外固定架/新西兰大白兔/股骨/骨折,延迟愈合分类
医药卫生引用本文复制引用
张志天,王淑民,赵景新,张猛..股骨延迟愈合外固定模型兔的建立与评估[J].中国组织工程研究,2017,21(20):3190-3195,6.
