中国组织工程研究2017，Vol.21Issue(21)：3400-3406,7.DOI:10.3969/j.issn.2095-4344.2017.21.020
骨髓间充质干细胞在多种疾病治疗中的应用进展
Clinical application and advancement of bone marrow mesenchymal stem cells in the treatment of various diseases
摘要
Abstract
BACKGROUND:Bone marrow mesenchymal stem cells as non-hematopoietic stem cells from the mesoderm mostly come from the bone marrow, which have a stronger self-renewal ability, multilineage differentiation ability and low immunogenicity and are easy to receive the introduction of foreign genes. Therefore this kind of cells have become the research hotspot in recent years. OBJECTIVE:To summarize the latest clinical application and advancement of bone marrow mesenchymal stem cels in the treatment of various diseases. METHODS: PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and SinoMed (http://www.sinomed.ac.cn/zh/) databases were searched by the first author using the keywords of "bone marrow mesenchymal stem cells, therapy" to identify the relevant articles published in English and Chinese, respectively, from 2011 to 2016. After excluding repetitive, irrelevant or Meta-analysis literatures, we enrolled 49 literatures for final analysis. RESULTS AND CONCLUSION:Studies on bone marrow mesenchymal stem cells have achieved new grades in the treatment of respiratory system disease, cardiovascular disease, urinary system disease, nervous system disease, liver disease, diabetes mellitus, hematological system disease, autoimmune disease, graft-versus-host disease, motor system disease, although its application has the risk of oncogenicity. Further investigation on the oncogenicity of bone marrow mesenchymal stem cells will be gradually explored, aiming to a better clinical use of bone marrow mesenchymal stem cells.关键词
干细胞/骨髓干细胞/骨髓间充质干细胞/组织工程/治疗/基因表达/致瘤性/国家自然科学基金分类
医药卫生引用本文复制引用
张凯辉,徐宝山,杨强..骨髓间充质干细胞在多种疾病治疗中的应用进展[J].中国组织工程研究,2017,21(21):3400-3406,7.基金项目
国家自然科学基金资助项目(81272046) （81272046）
天津市卫生局攻关课题(14KG121,15KG125) （14KG121,15KG125）
天津市科学技术委员会课题(15JCYBJC25300)the National Natural Science Foundation of China, No. 81272046 （15JCYBJC25300）
Tackling Key Subject of the Tianjin Health Bureau, No. 14KG121 and 15KG125 （）
the Project of Tianjin Science and Technology Committee, No. 15JCYBJC25300 （）
