西南国防医药2017，Vol.27Issue(7)：653-655,3.DOI:10.3969/j.issn.1004-0188.2017.07.002
雌激素对去卵巢糖尿病缺血性心肌病大鼠代谢的影响
Impacts of estrogen on metabolism in ovariectomized rats with diabetic ischemic cardiopathy
摘要
Abstract
Objective To observe the impacts of estrogen on metabolism in ovariectomized rats with type 2 diabetes mellitus (T2DM) ischemic cardiopathy and explore its role in the protection of diabetic ischemic cardiomyopathy.Methods Models of ovariectomized rats with T2DM ischemic cardiopathy were established,and the rats were fed for three months under different conditions;and then,the serum sex hormone binding globulin (SHBG),estrogen,blood sugar,blood lipid and insulin levels in rats in each group were detected to observe the impacts of estrogen replacement therapy (ERT) on various indexes.Results Compared with the control group,the SHBG and estradiol(E2) levels in T2DM group and coronary heart disease (CHD) group decreased greatly,while follicle stimulating hormone(FSH) and luteinizing hormone(LH) levels increased significantly (P ＜ 0.05);the SHBG and estrogen levels between the T2DM group and the CHD group had no significant difference (P ＞ 0.05);compared with T2DM group and CHD group,the SHBG and E2 levels in the treatment group increased greatly,while FSH and LH levels decreased significantly (P ＜ 0.05).Compared with the control group,the blood low-density lipoprotein (LDL),TG,fasting blood glucose and insulin levels in T2DM group and CHD group increased significantly,while HDL decreased greatly(P ＜ 0.05).These indexes between the T2DM group and the CHD group showed no significant difference (P ＞ 0.05);compared with T2DM group and CHD group,the LDL and FINS in the treatment group decreased (P ＜ 0.05),HDL increased greatly (P ＜ 0.05),and TG had no significant change (P ＞ 0.05).Conclusion ERT can lower the glucose in rats with diabetic ischemic cardiopathy,improve blood lipid ratio and increase insulin sensitivity.关键词
雌激素/去卵巢大鼠/糖尿病/缺血性心肌病/代谢Key words
estrogen/ovariectomized rats/diabetic ischemic cardiopathy/metabolism分类
医药卫生引用本文复制引用
姚德厚,贾小兵,姚宝清,张鼎圣,王少华,黄煦,付思云..雌激素对去卵巢糖尿病缺血性心肌病大鼠代谢的影响[J].西南国防医药,2017,27(7):653-655,3.基金项目
全军“十一·五”科研课题基金面上项目B类(2006B201) （2006B201）
