西南国防医药2017，Vol.27Issue(7)：700-703,4.DOI:10.3969/j.issn.1004-0188.2017.07.019
同轴静电纺丝法制备PLGA-壳聚糖/CIP电纺纤维膜及相关研究
Fabrication of PLA-CS/CIP electrospun fiber membrane by co-electrospinning and correlational research
祖林燕 1吴华 1胡丽云2
作者信息
- 1. 230000合肥,合肥市滨湖医院药剂科
- 2. 中国人民解放军东海舰队外洋螺医院
- 折叠
摘要
Abstract
Objective To evaluate the relevant physicochemical properties,degradation,release and antibacterial activity of the poly lactic acid (PLA)-chitosan (CS)/ciprofloxacin(CIP) electrospun fiber membrane prepared by co-electrospinning and lay foundation for further research on dru-loading slow-release GTR/GBR membrane.Methods PLA-CS/CIP electrospun fiber membrane was prepared by c-electrospinning.The surface morphology and fiber coaxial structure of fibrous membrane were observed and fiber diameter,mechanical properties and CIP release rate were measured.The antibacterial activity was measured after bacterial culture.Results The coaxial PLA-CS/CIP electrospun fiber membrane prepared had uniform diameter,smooth fiber and random direction,without beading;,the diameter was (794±73)nm,significantly greater than that of blending PLA-CS/CIP electrospun fiber membrane and PLA-CS electrospun fiber membrane(P ＜ 0.05).The CIP contained in the membrane could be continuously released for 10 days.The antibacterial activity was excellent.Conclusion The PLA-CS/CIP electrospun fiber membrane prepared by co-electrospinning has excellent physical and chemical property and good slow-release and antimicrobial effects,and has further application prospects to new GTR/GBR membrane.关键词
聚乳酸/壳聚糖/环丙沙星/静电纺丝/GTRKey words
PLA/CS/CIP/electrospinning/GTR分类
医药卫生引用本文复制引用
祖林燕,吴华,胡丽云..同轴静电纺丝法制备PLGA-壳聚糖/CIP电纺纤维膜及相关研究[J].西南国防医药,2017,27(7):700-703,4.
