信阳师范学院学报（自然科学版）2017，Vol.30Issue(2)：340-344,5.DOI:10.3969/j.issn.1003-0972.2017.02.034
Bcl-2蛋白质家族调控细胞凋亡机制的研究进展
Research Progress on the Molecular Mechanism of Apoptosis Regulated by Bcl-2 Protein Families
摘要
Abstract
Apoptosis is a form of programmed cell death controlled genetically in response to apoptotic stimuli or signals.Apoptosis induced by mitochondrial pathway is mainly regulated by the complex interplay between B-cell lymphoma 2 (Bcl-2) protein family members.However,the detailed interplay mode remains debatable.In this paper,the molecular mechanism of the interaction between Bcl-2 family members was firstly reviewed.Secondly,the mathematical models were summarized about bistability emerged from apoptosis and the interaction mode of Bcl-2 family proteins,respectively.Finally,numerical simulations and bifurcation analysis were conducted for the three interplay modes(i.e.direct activation mode,indirect activation mode and unified mode) proposed by the biologists.The results are in favor of the unified mode as a most plausible interplay mode.The work is hoped to improve our understanding of the molecular mechanism in the pathological cells and to provide insights into the manipulation of the diseases caused by abnormal apoptosis,such as cancer and Alzheimer's disease.关键词
细胞凋亡/Bcl-2蛋白质家族/统一模式/双稳性/癌症治疗Key words
apoptosis/Bcl-2 protein family/unified mode/bistability/cancer therapy分类
数理科学引用本文复制引用
尹智勇,杨俊元,祁宏..Bcl-2蛋白质家族调控细胞凋亡机制的研究进展[J].信阳师范学院学报（自然科学版）,2017,30(2):340-344,5.基金项目
国家自然科学基金项目(11504214) （11504214）
