新医学2017，Vol.48Issue(7)：467-471,5.DOI:10.3969/j.issn.0253-9802.2017.07.007
改良FSP、CVHI联合Lp-PLA2预测脑卒中
Modified Framingham stroke profile, cerebral vascular hemodynamic indexes and Lp-PLA2 in prediction of stroke
摘要
Abstract
Objective To assess the value of the model established by modified Framingham risk score (FSP),cerebral vascular hemodynamic indexes (CVHI) combined with lipoprotein phospholipase A2 (Lp-PLA2) in prediction of stroke.Methods Clinical data of 101 patients with primary ischemic stroke and 156 community residents without stroke were collected.Multivariate Logistic regression analysis was performed to evaluate the values of FSP,CVHI and Lp-PLA2 in prediction of stroke.FSP,FSP+CVHI,FSP+Lp-PLA2 and FSP+CVHI+Lp-PLA2 prediction models were established.The predictive ability of each model was analyzed by using the area under receiver operating characteristic (ROC) curve (AUC).Results The risk of stroke was increased by 2.85,3.25 and 7.75 times when the FSP,CVHI and Lp-PLA2 were elevated by 1 grade (P=0.043,0.036 and <0.001).The ROC AUC of FSP,FSP+CVHI,FSP+Lp-PLA2 and FSP+CVHI+Lp-PLA2 prediction models were 0.588,0.845,0.858 and 0.936,respectively.Conclusion FSP+CVHI+Lp-PLA2 prediction model can effectively predict the incidence of stroke.关键词
脑卒中/弗明汉卒中风险评分/脑血流动力学/脂蛋白磷脂酶A2/风险预测模型Key words
Stroke/Framingham risk score/Cerebral vascular hemodynamic indexes/Lipoprotein phospholipase A2/Risk-prediction model引用本文复制引用
黄晓芸,付文金,梅志忠,陈智昌,方浩威,黄益洪,余映丽,卢婉娴..改良FSP、CVHI联合Lp-PLA2预测脑卒中[J].新医学,2017,48(7):467-471,5.基金项目
东莞市社会科技发展基金资助(2013108101023) （2013108101023）
