烟草科技2017，Vol.50Issue(6)：33-39,7.
基于猪口腔黏膜模型的口含烟烟碱渗透速率的影响因素
Factors influencing nicotine permeation rate from snus usage based on pig's oral mucosa model
摘要
Abstract
In order to investigate the nicotine permeation behavior in oral mucosa from snus, a device was designed which incorporated a matching skin permeation diffusion cell and a pig's oral mucosa. The effects of pressure, pH and moisture content on the nicotine permeation rate from snus were studied by combining the designed device with high performance liquid chromatography. The results showed that: 1) R2 of the standard curve of nicotine concentration was 1.000 in the range of 0.70-44.65 μg/mL and the recovery ranged from 96.45% to 98.96%. 2) Nicotine permeation from snus through the pig's oral mucosa as time presented a linear relationship, which belonged to a mucosa film-storage type. 3) Within 0.5-12.0 h, applying a pressure of 6.65× 10-2 N/cm2 significantly increased the permeation rate of nicotine. 4) When the moisture content of the snus sample was between 30% and 50% , the permeation rate of nicotine from snus at pH of 7.4-8.4 was significantly higher than that at pH of 5.3-5.4. Therefore, the nicotine permeation behavior of snus in oral mucosa could be regulated by changing the pressure and pH of snus.关键词
口含烟/口腔黏膜/烟碱/压力/pH/渗透速率Key words
Snus/Oral mucosa/Nicotine/Pressure/pH/Permeation rate分类
轻工纺织引用本文复制引用
艾明欢,陈超英,郑赛晶,张怡春..基于猪口腔黏膜模型的口含烟烟碱渗透速率的影响因素[J].烟草科技,2017,50(6):33-39,7.基金项目
上海烟草集团有限责任公司科技项目"新型无烟气烟草制品研发"(K2015-1-005Z). （K2015-1-005Z）
