应用化学2017，Vol.34Issue(7)：749-756,8.DOI:10.11944/j.issn.1000-0518.2017.07.160443
Ag(Ⅲ)-聚六亚甲基双胍配合物的合成及抗菌性能表征
Preparation and Antibiosis Characterization of Trivalent Ag(Ⅲ)-Polyhexamethylene Biguanide Hydrochloride Complex
摘要
Abstract
As the ligand and biological acceptable parts, polyhexamethylene biguanide hydrochloride(PHMB) are used for stabilizing Ag3+.A series of micron-sized quadricovalent cationic Ag(Ⅲ)-PHMB complexes was synthesized via oxidation of the monovalent silver, followed by stabilization of the oxidized high valence silver ions through complexation with PHMB.From the experimental result of agar well-diffusion method, it can be concluded that the antibacterial activity of Ag(Ⅲ)-PHMB complex is enhanced with increasing viscosity-average relative molecular mass of PHMB and weakened with the increase of the size of Ag(Ⅲ)-PHMB complex.The experimental results reveal that the complex yields the maximum antibacterial activity when the viscosity-average relative molecular mass of ligand is 5428.Though broth dilution method, micron-sized Ag(Ⅲ)-PHMB complex displays excellent antibacterial performance in low mass concentration towards Gram-positive and Gram-negative prokaryotes for excellent antibacterial activity of Ag3+.Compared with AgO, AgNO3 and PHMB, Ag(Ⅲ)-PHMB complex has lower minimal inhibitory concentration(MIC).With the increase of mass concentration, however, because of the reduction of the growth ratio of contacting area between Ag(Ⅲ)-PHMB complex and bacteria and the release radio of antimicrobial active substance, antibacterial activity of micron-sized Ag(Ⅲ)-PHMB complex shows slowly increasing rate.关键词
Ag(Ⅲ)-聚六亚甲基双胍配合物/粘均相对分子质量/抗菌性能Key words
Ag(Ⅲ)-polyhexamethylene biguanide hydrochloride complex/viscosity-average relative molecular mass/antibacterial performance分类
化学化工引用本文复制引用
赵鑫钰,陈迅,陆梓仪,陈雷光,朱贤锋,侯琳熙..Ag(Ⅲ)-聚六亚甲基双胍配合物的合成及抗菌性能表征[J].应用化学,2017,34(7):749-756,8.基金项目
环境友好类杀菌剂有机络合银关键技术的研发及产业化(2012B10023)和国家级大学生创新创业训练计划资助项目(201610386013) （2012B10023）
Supported by the Development and Industrialization of the Key Technology of the Environmental Friendly Silver-Organic Complex Bactericide(No.2012B00231), National Training Program of Innovation and Entrepreneurship for Undergraduates(No.201610386013) （No.2012B00231）
