应用化学2017，Vol.34Issue(7)：774-782,9.DOI:10.11944/j.issn.1000-0518.2017.07.160427
1-芳基-3-(3-(4-氧香豆素基)苯基)硫脲衍生物的合成及抑菌活性
Synthesis and Antibacterial Activity of 1-Aryl-3-(3-((2-oxo-2H-Chromen-4-yl)oxy)phenyl)thiourea Derivatives
摘要
Abstract
In order to develop thiourea derivatives with antibacterial activities, a series of novel 1-aryl-3-(3-((2-oxo-2H-chromen-4-yl)oxy)phenyl)thiourea derivative was synthesized from 4-hydroxycoumarin via chlorination, etherification, isothiocyanate formation and addition reactions.The structures of the title compounds were characterized by infrared spectroscopy(IR), nuclear magnetic resonance spectrocopy(NMR) and mass spectrometry(MS).The results show that title compounds exhibit excellent antibacterial activities against Xanthomonas oryzae pv.oryzae(Xoo) and Xanthomonas citri subsp.Citri(Xcc).Among of them, compounds 4k, 4l, 4m and 4n show excellent antibacterial activities against Xoo, with the EC50 values 137.42, 131.05, 129.23 and 117.43 mg/L, respectively, which were better than that of the control agent thiodiazole-copper(195.24 mg/L).Compounds 4k, 4l, 4m and 4n display considerable antibacterial activities against Xcc, with the EC50 values of 97.02, 94.31, 102.28 and 90.52 mg/L, respectively, which are better than that of thiodiazole-copper(120.25 mg/L).关键词
香豆素/硫脲类衍生物/合成/抑菌活性Key words
coumarin/thiourea derivatives/synthesis/antibacterial activities分类
化学化工引用本文复制引用
陈美航,张迅,王晓斌,陈仕学,舒华..1-芳基-3-(3-(4-氧香豆素基)苯基)硫脲衍生物的合成及抑菌活性[J].应用化学,2017,34(7):774-782,9.基金项目
贵州省科学技术资金资助项目([2011]2080) （[2011]2080）
铜仁学院博士基金项目(trxyDH1618) （trxyDH1618）
Supported by Natural Science Fund of Guizhou Province Education(No.[2011]2080), Dr Fund of Tongren University(No.trxyDH1618) （No.[2011]2080）
