MicroRNA-9通过NRP1抑制胃癌SGC-7901细胞上皮-间充质转化功能OA北大核心CSCDCSTPCD
MicroRNA-9 inhibits epithelial-mesenchymal transition in gastric cancer SGC-7901 cells by NRP1
目的: 研究微小RNA-9 (microRNA-9,miR-9)对胃癌SGC-7901细胞上皮-间充质转化(EMT)功能的影响及其相关机制.方法: SGC-7901胃癌细胞株分别转染miR-9 mimics和阴性对照序列(negative control mi-mic,NCM),作为miR-9组和NCM组,并设立未转染对照(control)组,采用RT-qPCR法检测各组细胞miR-9的含量,Transwell实验检测3组细胞迁移能力和侵袭能力,…查看全部>>
AIM: To investigate the inhibitory effect of microRNA-9 (miR-9) on epithelial-mesenchymal transition (EMT) in the gastric cancer SGC-7901 cells and its mechanism.METHODS: The gastric cancer cell line SGC-7901 was transfected with miR-9 mimics or negative control mimic (NCM), as miR-9 or NCM group, respectively.The SGC-7901 cells without transfection were used as control group.The expression level of miR-9 in each group was detected by RT-qPCR.The migra…查看全部>>
南寿山;王珏磊
天津市第五中心医院消化科,天津 300450天津市第五中心医院消化科,天津 300450
医药卫生
胃癌微小RNA-9上皮-间充质转化
Gastric cancerMicroRNA-9Epithelial-mesenchymal transition
《中国病理生理杂志》 2017 (7)
1191-1195,5
滨海新区卫生局基金资助项目(No.2013BWKY031)
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