中国当代儿科杂志2017，Vol.19Issue(8)：872-876,5.DOI:10.7499/j.issn.1008-8830.2017.08.006
中性粒细胞CD64和降钙素原联合检测在新生儿细菌感染早期诊断中的价值
Value of combined determination of neutrophil CD64 and procalcitonin in early diagnosis of neonatal bacterial infection
秦道建 1唐宗生 2陈淑丽 1许雪梅 1茅双根 1张士发1
作者信息
- 1. 皖南医学院第一附属医院 儿科,安徽 芜湖 241001
- 2. 皖南医学院第一附属医院中心实验室,安徽 芜湖 241001
- 折叠
摘要
Abstract
Objective To investigate the value of combined determination of neutrophil CD64 and procalcitonin (PCT) in the early diagnosis of neonatal bacterial infection. Methods According to discharge diagnosis, 37 neonates with bacterial infection were divided into sepsis (n=15) and ordinary infection (non-sepsis) groups (n=22). Twenty-one neonates without infection who were hospitalized during the same period of time were enrolled as the control group. Venous blood samples were collected immediately after admission. Flow cytometry was used to measure the serum level of neutrophil CD64. Chemiluminescence and immune transmission turbidimetry were used to measure the serum levels of PCT and CRP respectively. Results The sepsis group had higher serum levels of neutrophil CD64, PCT, and CRP than the control group (P<0.01), the ordinary infection group had a higher serum level of neutrophil CD64 than the control group (P<0.01), and the sepsis group had higher serum levels of PCT and CRP than the ordinary infection group (P<0.01). The areas under the ROC curve (AUC) of neutrophil CD64, PCT, and CRP in diagnosing bacterial infection were 0.818, 0.818, and 0.704 respectively, and the AUC of combined neutrophil CD64 and PCT was 0.926. A combination of neutrophil CD64 and PCT had a sensitivity of 97.29% and an accuracy of 89.65% in the early diagnosis of neonatal bacterial infection.The sensitivity and accuracy were higher than those of a combination of CRP and neutrophil CD64 or PCT as well as neutrophil CD64, PCT, or CRP alone for the early diagnosis of neonatal bacterial infection. Conclusions The combined determination of neutrophil CD64 and PCT can improve the sensitivity and accuracy in the diagnosis of neonatal bacterial infection, which helps with early identification of bacterial infection.关键词
CD64/降钙素原/细菌感染/败血症/诊断/新生儿Key words
CD64/Procalcitonin/Bacterial infection/Sepsis/Diagnosis/Neonate引用本文复制引用
秦道建,唐宗生,陈淑丽,许雪梅,茅双根,张士发..中性粒细胞CD64和降钙素原联合检测在新生儿细菌感染早期诊断中的价值[J].中国当代儿科杂志,2017,19(8):872-876,5.
