中国动脉硬化杂志2017，Vol.25Issue(7)：701-704,4.
载脂蛋白M基因rs707921位点多态性与冠心病易感性的关系
Association between apolipoprotein M gene rs707921 site polymorphism and susceptibility to coronary heart disease
摘要
Abstract
Aim To investigate the association between apolipoprotein (ApoM) gene and coronary heart disease (CHD) by detecting the polymorphism of ApoM rs707921 site.Methods The polymorphism of ApoM rs707921 site was detected by single fluorescent labeling probe technique in 111 cases of CHD patients and 248 cases of control group.The distribution of genotype and allele frequency was analyzed.Results The frequencies of ApoM rs707921 genotype (AA,AC and CC) were 1.8％,13.5％ and 84.7％ in CHD group,2.0％,25.4％ and 72.6％ in control group,respectively,there was significant difference between the two groups (P =0.039).The frequencies of A and C allele in ApoM rs707921 site were 8.6％ and 91.4％ in CHD group,14.7％ and 85.3％ in control group,respectively,the difference between the two groups was statistically significant (P =0.023).Triglyceride level of AC+AA genotype was significantly low-er than that of CC genotype in CHD group (P =0.043).There was no significant difference in the severity of coronary artery lesion between different genotypes of rs707921 polymorphism in CHD group (P＞0.05).Conclusion A allele of ApoM gene rs707921 site may reduce the risk of CHD,but has nothing to do with the severity of coronary heart disease.关键词
载脂蛋白M/冠心病/单核苷酸多态性Key words
Apolipoprotein M/Coronary heart disease/Single nucleotide polymorphism分类
医药卫生引用本文复制引用
俞天虹,周瑞珏,于洋,郑璐,柯海燕,杨晓宇,杨玲,孙晋亮,邵山,罗光华..载脂蛋白M基因rs707921位点多态性与冠心病易感性的关系[J].中国动脉硬化杂志,2017,25(7):701-704,4.基金项目
常州市科技局科技支撑(社会发展)项目(20135063) （社会发展）
