摘要
Abstract
Aim To explore the serum levels of interleukin-1 (IL-1) and interleukin-6 (IL-6) in patients with chronic heart failure accompanied with renal damage and its clinical significance.Methods 220 New York Heart Association (NYHA) functional class Ⅱ ～ Ⅳ patients with chronic heart failure were enrolled in this study.Serum levels of blood urea nitrogen (BUN),serum creatinine (SCr),N-terminal pro-B-type natriuretic peptide (NT-proBNP),IL-1 and IL-6 were detected,microalbuminuria (MAU) was detected randomly,left ventricular ejection fraction (LVEF) was measured by echocardiography,glomerular filtration rate (eGFR) was calculated.The levels of IL-1,IL-6,NT-proBNP,MAU and eGFR in different cardiac function groups were compared and the levels of IL-1 and IL-6 in different renal function groups were compared.The relationship between IL-1,IL-6 and NYHA functional classification,NT-proBNP,LVEF,eGFR and MAU were analysed.Results The serum levels of IL-1,IL-6,NT-proBNP and MAU in NYHA Ⅲ ～ Ⅳ groups were higher than NYHA Ⅱ group (P＜0.05),the eGFR of NYHA Ⅲ ～ Ⅳ groups were lower than NYHA Ⅱ group (P＜0.05),and the levels of IL-1,IL-6,NT-proBNP and MAU in NYHA Ⅳ group were higher than NYHA Ⅲ] group (P＜ 0.05).In NYHA functional class Ⅲ ～Ⅳ patients the serum levels of IL-1,IL-6,NT-proBNP and MAU in 30％ ≤ EF ≤ 50％ group were higher than EF＞50％group (P＜0.05),the eGFR of 30％ ≤ EF ≤ 50％ group were lower than EF＞50％ group (P＜0.05),the serum levels of IL-1,IL-6,NT-proBNP and MAU in EF＜30％ group were higher than 30％ ≤ EF ≤ 50％ group (P＜0.05).In NYHA functional class Ⅲ ～ Ⅳpatients the serum levels of IL-1,IL-6 in renal dysfunction group [eGFR＜ 60 mL/(min.1.73m2)] were higher than normal renal function group [eGFR ≥ 60 mL/(min.1.73m2)] (P ＜ 0.05).The serum levels of IL-1,IL-6 and eGFR had no obvious difference in different basic etiologies groups (P＞ 0.05).The serum levels of IL-1 and IL-6 were positively correlated with the NYHA functional classification,MAU and NT-proBNP (P＜0.05),negatively correlated with LVEF and eGFR (P＜0.05).Conclusion The serum levels of IL-l and IL-6 are elevated in patients with chronic heart failure and correlated with the severity of chronic heart failure and renal damage,and detecting IL-1,IL-6 may provide some assistances for assessing the severity of heart failure in clinical.关键词
慢性心力衰竭/白细胞介素1/白细胞介素6/肾功能Key words
Chronic heart failure/Interleukin-1/Interleukin-6/Renal function分类
医药卫生
