中国感染控制杂志2017，Vol.16Issue(7)：600-605,6.DOI:10.3969/j.issn.1671-9638.2017.07.003
内科重症监护病房铜绿假单胞菌医院感染同源性及临床特点
Homology and clinical characteristics of healthcare-associated infection with Pseudomonas aeruginosa in medical intensive care unit
张萍 1刘红梅 2陈愉 3赵思宏 1李玉荣 1宋争昌 2赵立4
作者信息
- 1. 中国医科大学附属盛京医院,辽宁 沈阳 110004
- 2. 沈阳市第四人民医院,辽宁 沈阳 110031
- 3. 朝阳市第四人民医院,辽宁 朝阳 122000
- 4. 泰山医学院附属医院,山东 泰山 271000
- 折叠
摘要
Abstract
Objective To study the homology and clinical characteristics of healthcare-associated infection(HAI) due to Pseudomonas aeruginosa (P.aeruginosa)in medical intensive care unit (MICU),so as to guide the clinical prevention of P.aeruginosa transmission and improve therapeutic effect.Methods 55 P.aeruginosa strains isola-ted from 25 patients with HAI in the MICU of a hospital in January-December 2014 were performed pulsed-field gel electrophoresis (PFGE)homology analysis and clustering analysis,clinical characteristics,antimicrobial resistance, and transmission characteristics were analyzed.Results A total of 25 patients were investigated,with an average age of (69.62±2.13)years,mean hospital stay (49.34±3.18)days;prior to the isolation of P.aeruginosa, 84.00% of patients were treated with broad-spectrum antimicrobial agents for >2 weeks,76.00% of patients had been admitted to MICU,and 52.00% had a ventilator-assisted ventilation.55 strains of P.aeruginosa were mainly A,F,H,K,N,V,and W,which were the main epidemic strains;patients infected with A,F,H and K strains all had cross in their hospital stay;PFGE profiles of isolates from 4 patients during different periods showed different strain patterns;resistance rates of P.aeruginosa to ceftazidime (72.73%), piperacillin/tazobactam (70.91%),and imipenem(70.91%)were all high,resistance rate to amikacin was the lowest(25.45%).Conclusion Management of antimicrobial agents should be strengthened in medical institutions,HAI control meas-ures should be strengthened,so as to prevent the transmission of multidrug-resistant and extensively drug-resistant bacteria in hospitals.关键词
重症监护病房/铜绿假单胞菌/脉冲场凝胶电泳/同源性/传播特点/临床分析Key words
intensive care unit/Pseudomonas aeruginosa/pulsed-field gel electrophoresis/homology/spread characteristic/clinical analysis分类
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张萍,刘红梅,陈愉,赵思宏,李玉荣,宋争昌,赵立..内科重症监护病房铜绿假单胞菌医院感染同源性及临床特点[J].中国感染控制杂志,2017,16(7):600-605,6.
