中国感染控制杂志2017，Vol.16Issue(7)：606-609,4.DOI:10.3969/j.issn.1671-9638.2017.07.004
大肠埃希菌及肺炎克雷伯菌耐药性与抗菌药物使用强度相关性
Correlation between antimicrobial resistance and antimicrobial use density of Escherichia coli and Klebsiella pneumoniae
摘要
Abstract
Objective To investigate antimicrobial resistance of Escherichia coli (E.coli)and Klebsiella pneumoniae (K.pneumoniae),antimicrobial use density(AUD),as well as relation between antimicrobial resistance and AUD in a ter-tiary first-class hospital.Methods Antimicrobial resistance rates of clinically-isolated E.coli and K.pneumoniae,AUD of carbapenems and quinolones,as well as relation between resistance and AUD in 2013-2015 were statistically analyzed. Results Correlation analysis of antimicrobial resistance of bacteria and AUD showed that the decrease in resistance rate of E.coli to levofloxacin was related to the decrease in the use density of quinolones(r=0.61,P=0.03);increase in resist-ance rate of K.pneumoniae to imipenem was related to the increase in the use density of carbapenems(r=0.78,P<0.01). Conclusion Antimicrobial use is one of the causes of bacterial resistance,management on antimicrobial use needs to be strengthened to reduce the threat of bacterial resistance to human health.关键词
大肠埃希菌/肺炎克雷伯菌/抗菌药物/抗菌药物使用强度/AUD/耐药性Key words
Escherichiacoli/Klebsiellapneumoniae/antimicrobial agent/antimicrobial use density/AUD/drug resistance分类
医药卫生引用本文复制引用
郑伟,茅一萍,韩方正,周宏,翟仁旭,曹剑梅,赵新忠,姜新国..大肠埃希菌及肺炎克雷伯菌耐药性与抗菌药物使用强度相关性[J].中国感染控制杂志,2017,16(7):606-609,4.基金项目
江苏省卫生计生委预防医学科研课题(Y2015067) （Y2015067）
