中国临床药理学与治疗学2017，Vol.22Issue(6)：601-605,5.
大蒜辣素对db/db糖尿病小鼠心肌细胞凋亡及Pink1/Parkin信号通路的影响
Effect of allicin on apoptosis and Pink1/Parkin signal path of cardiomyocyte in db/db mice
摘要
Abstract
AIM:To observe the effect of allicin on apoptosis and Pink1/Parkin signal path of cardiomyocyte in db/db mice.METHODS:Diabetes models were randomly divided into diabetes model group and allicin group.After 21 days of injection,all mice were sacrificed and samples were gathered.Cell apoptosis was analyzed using TUNEL.The mRNA and protein expression level of Pink1,Parkin and Mfn1 were detected by qRT-PCR and Western blot.RESULTS:Severe cardiomyocyte apoptosis,lower expression of Parkin,and higher expression of Mfn1 were observed in diabetes model group,while in allicin group,such changes were improved.CONCLUSION:Allicin can effectively restrain cardiomyocyte apoptosis and protect cardiomyocyte by activating Pink1/Parkin signal path.关键词
大蒜辣素/心肌细胞/凋亡/db/db小鼠/ParkinKey words
allicin/cardiomyocyte/apoptosis/db/db mice/Parkin分类
医药卫生引用本文复制引用
荆哲,刘峰舟,郭文韵,焦丕齐,陈永清..大蒜辣素对db/db糖尿病小鼠心肌细胞凋亡及Pink1/Parkin信号通路的影响[J].中国临床药理学与治疗学,2017,22(6):601-605,5.基金项目
国家自然科学基金青年科学基金项目(81400197) （81400197）
