中国临床药理学与治疗学2017，Vol.22Issue(6)：622-626,5.
人urotensin Ⅱ对大鼠心肌缺血缺氧性损伤的保护作用机制
Mechanism human urotensin on myocardial ischemia-reperfusion injury in rats
摘要
Abstract
AIM:To investigate the mechanism of human urotensin Ⅱ (hUⅡ) against myocardial ischemia-reperfusion injury in rats.METHODS:On the ligation of anterior decending branch of left coronery artery model,changes of electrocardiogram (ECG) were observed,myocardial infarction volume and inducible nitric oxide synthesis (iNOS) mRNA in myocardial tissue were measured.RESULTS:0.47,1.4 and 4.2 μg/kg hU Ⅱ obviously inhibited ECG ST segment elevation and myocardial infarction volume in ischemia-reperfusion injured rats;4.2 μg/kg hUⅡ significantly improved changes of ultrastructure in myocardial cells and increased the expression of iNOS mRNA in myocardium in rats subjected to myocardial ischemia-reperfusion;UT receptor antagonist urantide (10 nmol/kg) significantly antagonized inhibitory effects of hUⅡ 1.4 and 4.2 μg/kg for ECG ST segment elevation and myocardial infarction.CONCLUSION:Mechanism of hUⅡ against myocardial ischemic injury in rats is related to activation of UT receptor and promotion of nitric oxide production.关键词
人urotensin Ⅱ/urantide/心肌缺血再灌注/诱导型一氧化氮合酶/拮抗Key words
human urotensin Ⅱ/urantide/myocardial ischemia-reperfusion/inducible nitric oxide synthesis/antagonize分类
医药卫生引用本文复制引用
王荣俊,丁波..人urotensin Ⅱ对大鼠心肌缺血缺氧性损伤的保护作用机制[J].中国临床药理学与治疗学,2017,22(6):622-626,5.基金项目
安徽省高校省级科研项目(2006KJ313B) （2006KJ313B）
