中国临床药理学与治疗学2017，Vol.22Issue(6)：640-644,5.
高通量低能量激光照射诱导人肺腺癌细胞凋亡过程中survivin的抗凋亡效应的研究
Mechanism of the inhibition of apoptosis by survivin during high fluence low-power laser irradiation-induced apoptosis
摘要
Abstract
AIM:Recent years,some studies showed that high fluence low-power laser irradiation (HF-LPLI) can induce apoptosis whereas whether survivin plays an important role in this process and its regulation mechanism is not clear.This article mainly studies the distribution of survivin in nuclear and cytoplasm and the change of expression of survivin under the HF-LPLI treatment.METHODS:The research real-time monitors the dynamic process of survivin under the HF-LPLI treatment with the GFP-survivin in ASTC-α-1 cells.RESULTS:The results showed that survivin translocated to nuclear at 3 hours and the expression quantity of survivin advances with time by LPLI(240 J/cm2).CONCLUSION:The results implicated that survivin may be regulated by HF-LPLI and regulates some cell signaling proteins,for instance,p53,Akt.The further study will explore that survivin regulate the precise transcription factors and the regulation mechanism.关键词
生存素/细胞凋亡/高通量低能量激光照射Key words
survivin/apoptosis/high fluence low-power laser irradiation分类
医药卫生引用本文复制引用
储冀汝,沈杰..高通量低能量激光照射诱导人肺腺癌细胞凋亡过程中survivin的抗凋亡效应的研究[J].中国临床药理学与治疗学,2017,22(6):640-644,5.基金项目
皖南医学院中青年自然科学基金项目(WK2012F09) （WK2012F09）
安徽省自然科学基金项目(1408085MH163) （1408085MH163）
安徽省高等学校自然科学研究项目(KJ2015A155) （KJ2015A155）
国家自然科学基金项目(81641141) （81641141）
