中国临床药理学与治疗学2017，Vol.22Issue(6)：664-667,4.
坦度螺酮治疗伴有焦虑抑郁的功能性消化不良的疗效及对生存质量的影响
Efficacy of tandospirone in treating functional dyspepsia accompanied by anxiety and depression and its influence on quality of life
摘要
Abstract
AIM:To observe the clinical efficacy of tandospirone in the treatment of functional dyspepsia(FD) accompanied by anxiety and depression and its influence on quality of life.METHODS:Ninety-eight cases with FD accompanied by anxiety and depression were randomly divided into treatment group and control group (n =49).Patients of control group were treated with oral pantoprazole and mosapride.On the basis of control group,the treatment group was given oral tandospirone for four weeks.The therapeutic effect and adverse effects were observed and compared in both groups.RESULTS:Compared with before treatment,the scores of FD symptoms,Hamilton Rating Scale for Despression (HAMD) and Hamilton Anxiety Scale (HAMA) in treatment group decreaed significantly after treatment,while the score of Functional Digestive Disorders Quality of Life Questionnaire (FDDQL) increased significantly (all P ＜ 0.01);the decrease of FD symptoms,HAMD,HAMA scores and the increase of FDDQL scores of treatment group were greater than those of control group (all P ＜ 0.01).The total effective rate of treatment group was significantly higher than that of control group (87.5 ％ vs.63.3％,x2 =6.49,P ＜ 0.05).There was no obvious adverse effect recurred in both groups.CONCLUSION:Tandospirone is a safe and effective drug for FD accompanied by anxiety and depression;it can effectively improve the symptoms of anxiety,depression and quality of life of patients.关键词
功能性消化不良/坦度螺酮/焦虑/抑郁/生存质量Key words
functional dyspepsia/tandospirone/anxiety/depression/quality of life分类
医药卫生引用本文复制引用
龚晓兵,李淑珍,黄叶盛,马彦,柳永刚,蒋亚斌,杨见权..坦度螺酮治疗伴有焦虑抑郁的功能性消化不良的疗效及对生存质量的影响[J].中国临床药理学与治疗学,2017,22(6):664-667,4.基金项目
国家自然科学基金(31170941,81671946) （31170941,81671946）
广东省医学科学技术研究基金(A2015479) （A2015479）
