中国临床药理学与治疗学2017，Vol.22Issue(6)：680-683,4.
复方倍他米松注射液联合埃索美拉唑治疗喉接触性肉芽肿的临床研究
Effect of intralesional diprospan injection combined with esomeprazole acid-suppressive on laryngeal contact granuloma
摘要
Abstract
AIM:To investigate the efficacy and security of intralesional compound betamethasone injection combined with esomeprazole acid-suppressive therapy for the treatment of laryngeal contact granuloma.METHODS:Seventy-six patients with laryngeal contact granuloma diagnosed from March 2012 to March 2016 were reviewed.Twenty-seven patients took intralesional compound betamethasone injection combined with esomeprazole acid-suppressive therapy as treatment group,the other 67 patients only received esomeprazole acid-suppressive therapy as control group.Control group was treated with oral esomeprazole,20 mg per time,twice a day for 1 month,followed by esomeprazole 10 mg per time,each morning for half a month,then followed by esomeprazole 10 mg per time,each 2 days for half a month.Treatment group was treated with oral esomeprazole plus intralesional compound betamethasone injection,0.3-0.5 mL per time,and one time for each month for less than 3 consecutive months.The clinical data of these patients were analyzed.RESULTS:The cure rate was significantly improved in the treatment group (70.37％,19/27) compared with that in the control group (46.94％,23/49),and the cure time in the treatment group [(2.62 ± 0.37) months] was significantly shorter than that in the control group[(5.16 ±0.85) months].Meanwhile,in those patients with Farwell Ⅲ and Ⅳ grade lesions,the cure rate in the treatment group (60.00％,6/10) was also significantly higher than that in the control group (14.29％,3/21).In both groups,the adverse drug reaction mainly included dyspepsia,gasteremphraxis and hiccough.There were no significant differences (P =0.695) in the rate of adverse drug reaction between treatment group (11.11％) and control group (14.29％).CONCLUSION:Intralesional compound betamethasone injection combined with esomeprazole acid-suppressive therapy can be recommended as a safe and effective alternative therapy for laryngeal contact granuloma,especially for the refractory granuloma.关键词
埃索美拉唑/复方倍他米松注射液/喉接触性肉芽肿/安全性Key words
esomeprazole/compound betamethasone injection/laryngeal contact granuloma/safety分类
医药卫生引用本文复制引用
方潇碧,周琴双,廖志苏..复方倍他米松注射液联合埃索美拉唑治疗喉接触性肉芽肿的临床研究[J].中国临床药理学与治疗学,2017,22(6):680-683,4.基金项目
浙江省自然科学基金资助项目(LY15H130004) （LY15H130004）
