中国临床药理学杂志2017，Vol.33Issue(11)：963-965,3.DOI:10.13699/j.cnki.1001-6821.2017.11.001
亚低温环境下盐酸纳洛酮注射液治疗重症颅脑损伤的临床研究
Clinical trial of naloxone hydrochloride in the treatment of severe traumatic brain injury in mild hypothermia environment
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of naloxone hydrochloride in the treatment of severe traumatic brain injury in mild hypothermia environment.Methods A total of 162 cases with severe traumatic brain injury were randomly divided into control group (n =81 cases) and treatment group (n =81 cases).Control group was given conventional therapy and mild hypothermia treatment.On the basis of control group,treatment group was received naloxone hydrochloride injection 0.3 mg · kg-1 · d-1,continued intravenous infusion,qd.Two groups were both treated for 7 d.The levels of serum matrix metalloproteinase-9 (MMP-9) and S100 calcium-binding protein (S100-B),clinical efficacy and safety were compared in two groups.Results After treatment,the total effective rates in treatment group and control group were 82.72％ (67/81 cases),67.91％ (55/81 cases),with significant difference (P ＜ 0.05).After treatment,serum MMP-9 were (38.64 ±5.42),(24.48 ±3.41) μg · mL-1 in control group and treatment group;serum S100-B were (0.98 ± 0.14),and (0.15 ± 0.05) μg · L-1 in control group and treatment group.There was statistically significant difference between two groups (P ＜ 0.05).The adverse drug reactions including gastrointestinal reactions,liver and renal dysfunction in control and treatment groups,the incidence were 11.11％ (9/81 cases) and 7.41％ (6/81 cases),respectively,without significant difference (P ＞ 0.05).Conclusion The treatment of naloxone hydrochloride can significantly reduce the levels of serum MMP-9 and S100-B in patients with severe traumatic brain injury in mild hypothermia environment,and improve clinical efficacy with high safety.关键词
亚低温环境/盐酸纳洛酮/重症颅脑损伤/金属蛋白酶-9/S100蛋白Key words
mild hypothermia environment/naloxone hydrochloride/severe traumatic brain injury/metalloproteinase-9/S-100 calcium-blinding protein分类
医药卫生引用本文复制引用
高嵘,单春雷..亚低温环境下盐酸纳洛酮注射液治疗重症颅脑损伤的临床研究[J].中国临床药理学杂志,2017,33(11):963-965,3.基金项目
江苏省2011年六大才人高峰基金资助项目(100) （100）
