中国临床药理学杂志2017，Vol.33Issue(11)：977-979,3.DOI:10.13699/j.cnki.1001-6821.2017.11.005
负载妥布霉素的硫酸钙治疗老年慢性骨髓炎的临床研究
Clinical trial of Osteoset-T in the treatment of elderly patients with chronic osteomyelitis
摘要
Abstract
Objective To observe the clinical efficacy and safety of Osteoset-T in the treatment of elderly patients with chronic osteomyelitis.Methods A total of 58 elderly patients with chronic osteomyelitis were randomly divided into control group and treatment group with 26 cases per group.Two groups were treated with debridement.After debridement,control group was given gentamicin bone cement (4 mg · g-1) filling the cavity,the treatment group was given Osteoset-T (4％ Tobramycin)filling the cavity.The clinical efficacy,lysozyme (LZM),C reactive protein (CRP) and adverse drug reactions were compared between the two groups.Results After treatment,the total effective rates in treatment and control groups were 88.46％ (23/26 cases) and 65.38％ (17/26 cases) with significant difference (P ＜ 0.05).After treatment,LZM in treatment and control groups were (22.45 ± 1.78),(18.54 ±1.32) μg · L-1;CRP in treatment and control groups were (1.58 ± 0.22),(3.86 ± 0.43) mg · L-1,with significant differences (P ＜ 0.05).The adverse drug reactions in treatment group were local infiltration fluid,which in control group were local infiltration fluid and delayed wound healing.The incidences of adverse drug reactions in treatment and control groups were 3.85％ and 7.69％ without significant difference (P ＞0.05).Conclusion Osteoset-T has a definitive clinical efficacy in the treatment of elderly patients with chronic osteomyelitis,which can improve the levels of LZM,reduce the levels of CRP,without increasing the incidence of adverse drug reactions.关键词
负载妥布霉素的硫酸钙/慢性骨髓炎/安全性Key words
Osteoset-T/chronic osteomyelitis/safety分类
医药卫生引用本文复制引用
鲁宁,张春,张展..负载妥布霉素的硫酸钙治疗老年慢性骨髓炎的临床研究[J].中国临床药理学杂志,2017,33(11):977-979,3.基金项目
浙江省医药卫生科技计划基金资助项目(2012RCA011) （2012RCA011）
