中国临床药理学杂志2017，Vol.33Issue(11)：983-985,3.DOI:10.13699/j.cnki.1001-6821.2017.11.007
右美托咪定注射液对甲状腺手术患者术后镇痛作用的影响
Effect of dexmedetomidine injection on analgesic in patients after thyroid surgery
摘要
Abstract
Objective To observe the clinical efficacy and safety of dexmedetomidine on analgesic effect in patients after thyroid surgery.Methods A total of 102 patients after thyroid surgery were divided into control group and treatment group,each group 51 cases.Patients in both groups were given thyroid operation.Patients in both groups were given sulfentanyl 10 μg + 0.375％ ropivacaine mixture 20 mL before operation,granisetron hydrochloride injection 5 mg by intravenous drip,once a day after operation.Control group was given midazolam hydrochloride injection 0.03 mg · kg-1 by intravenous drip before operation.Treatment group was received dexmedetomidine hydrochloride injection 1 μg · kg-1 by intravenous drip before operation.The clinical efficacy,3-endorphin (3-EP),interleukin-6 (IL-6),C-reactive protein (CRP) and adverse drug reactions in two groups were observed.Results After treatment,total effective rates in treatment and control groups were 92.16％ (47/51 cases) and 78.43％ (40/51 cases),with significant difference (P ＜ 0.05).After treatment,β-endorphin in control group and treatment group were (268.47 ± 29.58),(284.47±30.05) pg· L-1,CRP were (4.47 ±0.54),(4.07 ±0.42)mg · L-1(P＜0.05).The adverse drug reactions in treatment group were lethargy,respiratory depression,nausea and vomiting,the incidence of adverse drug reactions was 5.88％ (3/51 cases).The adverse drug reactions in control group were itching,respiratory depression,drowsiness,nausea and vomiting,the incidence of adverse drug reactions was 11.76％ (6/51 cases,P ＞ 0.05).Conclusion The analgesic effect of dexmedetomidine after thyroid surgery is effective with high safety.关键词
舒芬太尼/右美托咪定/甲状腺手术/血清人β内啡肽/白细胞介素-6Key words
sulfentanyl/dexmedetomidine/thyroid surgery/serum β-endorphin/interleukin-6分类
医药卫生引用本文复制引用
朱利君,王慧君,王红珠..右美托咪定注射液对甲状腺手术患者术后镇痛作用的影响[J].中国临床药理学杂志,2017,33(11):983-985,3.基金项目
台州市计划课题基金资助项目(1401ky06) （1401ky06）
