中国临床药理学杂志2017，Vol.33Issue(11)：989-991,1018,4.DOI:10.13699/j.cnki.1001-6821.2017.11.009
坦索罗辛胶囊联合益气活血方治疗经皮肾镜超声弹道碎石术后肾损伤的临床研究
Clinical trial of tamsulosin capsules combined with Yiqihuoxue in the treatment of kidney injury after percutaneous nephrolithotripsy
摘要
Abstract
Objective To observe the clinical efficacy and safety of tamsulosin capsules combined with Yiqihuoxue in the treatment of kidney injury after percutaneous nephrolithotripsy.Methods A total of 52 patients with kidney injury after percutaneous nephrolithotripsy were randomly divided into control group and treatment group with 26 cases per group.Control group was treated with tamsulosin hydrochloride sustained release capsules 0.4 mg qd oral.Treatment group was given Yiqihuoxue 100 mL per time,oral,twice a day,morning and night,on the basis of the control group.Two groups were treated for 28 d.The clinical efficacy,levels of serum cystatin C (Cys-C),kidney injury molecule 1 (Kim-1),24 h urine protein (24 h Up),uric acid (UA),serum creatinine (SCr),urea nitrogen (BUN)and adverse drug reactions were compared between the two groups.Results After treatment,the total effective rates in treatment and control groups were 84.62％ (22/26 cases) and 57.69％ (15/26 cases),with significant differences (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:Cys-C were (1.65-± 0.27),(2.01-± 0.29) mg · L-1;Kim-1 were (31.38 ±3.76),(39.02 ±4.88)pg · mL-1;24 h Up were (0.52 ±0.07),(0.81 ±0.10) g · d-1;UA were (428.07 ± 50.39),(468.93 ± 52.26) μmol · L-1;SCr were (329.02 ± 40.11),(398.02 ±45.44) μmol · L-1;BUN were (14.09 ± 1.78),(18.00 ±2.44) mmol · L-1,with significant differences (P ＜ 0.05).The adverse drug reactions in treatment group were based on headache,diarrhea and hand foot skin reaction,which in control group were headache,hypertension and diarrhea.The incidence of treatment and control groups were 11.54％ and 15.38％ without significant difference (P ＞ 0.05).Conclusion Tamsulosin capsules combined with Yiqihuoxue has a definitive clinical efficacy in the treatment of kidney injury after percutaneous nephrolithotripsy,without increasing the incidence of adverse drug reactions.关键词
坦索罗辛胶囊/益气活血方/经皮肾镜超声弹道碎石术/肾损伤Key words
tamsulosin capsule/Yiqihuoxue/percutaneous nephrolithotomy lithotripsy/kidney injury分类
医药卫生引用本文复制引用
符贻翻,史南,沈仕兴..坦索罗辛胶囊联合益气活血方治疗经皮肾镜超声弹道碎石术后肾损伤的临床研究[J].中国临床药理学杂志,2017,33(11):989-991,1018,4.基金项目
国家医学教育发展中心医学研究课题基金资助项目(2010-37-03-004) （2010-37-03-004）
