中国临床药理学杂志2017，Vol.33Issue(11)：1007-1012,6.DOI:10.13699/j.cnki.1001-6821.2017.11.014
氟氧头孢对临床菌株的药代动力学及药效学研究
Pharmacokinetic and pharmacodynamic analysis of flomoxef against the clinical isolates of strains
冀希炜 1吕媛 1李耘 1卢炜2
作者信息
- 1. 北京大学第一医院临床药理研究,北京100191
- 2. 北京大学医学部药学院,北京100191
- 折叠
摘要
Abstract
Objective To evaluate the optimal administration regimen of flomoxef for the bacterial infection based on pharmacokinetic/pharmacodynamic (PK/PD) models.Methods A literature search was conducted in PubMed to capture the pharmacokinetic data of flomoxef.Minimum inhibitory concentrations (MICs) were determined using two-fold agar dilution method.The percent time that drug concentration exceeds the minimum inhibitory concentration (％fT＞MIC) was used as the PK/PD indicator correlated with efficacy.Monte Carlo simulation was employed to determine the appropriate regimens of flomoxef based on the probability of target attainment (PTA) against the clinical isolates of strains.Results The regimens of 1 g q6 h,1 g q8 h and 1 g q12 h with 1 hour infusion at 70％ of ％ fT＞MIC achieved 93.1％,89.1％ and 66.8％ of PTA against Escherichia coli (ESBL +),respectively.For the Klebsiella pneumoniae (ESBL+),these regimens achieved 81.8％,78.7％ and 62.3％ of PTA at ％fT＞MIC =70％.The regimen of 2 g q12 h achieved the similar PTA as 1g q6 h and 1 g q8 h at 50％ and 70％ of ％fT＞MIC,but not at higher ％ fT＞MIC.Furthermore,flomoxef also showed potent bactericidal activity against Escherichia coli (ESBL-),Klebsiella pneumoniae (ESBL-),methicillin-susceptible S.aureus (MSSA),methicillin-susceptible S.Epidermidis (MSSE) and Moraxella catarrhalis,etc.with all dosing regimens according to the PK/PD analysis.Conclusion As a time-dependent antibiotic,the clinical outcome of flomoxef can be improved by shortening dosing interval,extending infusion time and/or increasing dose.The first two strategies played more significant roles.关键词
氟氧头孢/药代动力学/药效学/剂量设计/抗菌药效指标达成概率/蒙特卡罗模拟Key words
flomoxef/pharmacokinetic/pharmacodynamic/dosing regimens/probability of target attainment/Monte Carlo simulation分类
医药卫生引用本文复制引用
冀希炜,吕媛,李耘,卢炜..氟氧头孢对临床菌株的药代动力学及药效学研究[J].中国临床药理学杂志,2017,33(11):1007-1012,6.
