中国临床药理学杂志2017，Vol.33Issue(12)：1075-1078,4.DOI:10.13699/j.cnki.1001-6821.2017.12.001
噻托溴铵吸入剂联合沙美特罗替卡松粉吸入剂对中重度慢性阻塞性肺疾病患者稳定期的肺功能及预后的影响
Effect of tiotropium bromide inhalation combined with salmeterol xinafoate and fluticasone propionate powder inhalation on pulmonary function and prognosis in the treatment of moderate and severe chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the effect of tiotropium bromide inhalation combined with salmeterol xinafoate and fluticasone propionate powder inhalation on pulmonary function and prognosis in treatment of patients with moderate and severe chronic obstructive pulmonary disease (COPD).Methods Eighty patients with moderate and severe COPD were randomly divided into control group (40 cases) and treatment group (40 cases).The control group was given salmeterol xinafoate and fluticasone propionate powder inhalation (50 μg/500 μg),every night and evening;the treatment group was given tiotropium bromide inhalation 18 μg on the basis of control group,every right before sleep.After 3 months treatment,the clinical efficacy,pulmonary function index,6-minunte walking test,score of dyspnea and inciden of adverse drug reactions were compared.Results The total effective rates in treatment group and control group were 87.50％ (35/40 cases) and 67.50％ (27/40 cases) 95.65％ respectively,the difference was statistically significant (P ＜ 0.05).The forced expiratory volume in one second (FEV1) of pulmonary function index in treatment group and control group were (2.22 ± 0.27),(1.80 ± 0.35) L,forced vital capacity (FVC) were (3.31 ± 0.40),(2.97 ± 0.59) L,FEV1/FVC were (65.36 ± 8.00) ％ and (56.97 ± 8.61) ％,results of 6-minute walking test were (421.68 ± 30.24),(401.26 ± 31.27) m;scores of dyspnea were 1.35 ± 0.29 and 1.70 ± 0.39 respectively,the differences were all statistically significant (P＜0.05).The main drug adverse reactions were dry mouth,nausea and hoarse voice.The incidences of drug adverse reactions in treatment group and control group were 15.00％ (6/40 cases) and 10.00％ (4/40 cases) respectively,the difference was not statistically significant(P ＞0.05).Conclusion Tiotropium bromide inhalation combined with salmeterol xinafoate and fluticasone propionate powder inhalation exerted positive effect with high safety in the treatment of moderate and severe COPD,indicating that the drug combination is worth to use in clinical practice.关键词
噻托溴铵/沙美特罗替卡松/中重度慢性阻塞性肺疾病/肺功能Key words
tiotropium bromide/salmeterol xinafoate and fluticasone propionate/moderate and severe chronic obstructive pulmonary disease/pulmonary function分类
医药卫生引用本文复制引用
金忠富,何小花,王玲霞..噻托溴铵吸入剂联合沙美特罗替卡松粉吸入剂对中重度慢性阻塞性肺疾病患者稳定期的肺功能及预后的影响[J].中国临床药理学杂志,2017,33(12):1075-1078,4.基金项目
浙江省医药卫生科技计划基金资助项目(2013RCA039) （2013RCA039）
