中国临床药理学杂志2017，Vol.33Issue(12)：1091-1093,3.DOI:10.13699/j.cnki.1001-6821.2017.12.006
四联疗法治疗2型糖尿病合并幽门螺杆菌阳性消化性溃疡的临床研究
Clinical trial of guadruple therapy for type 2 diabetic mellitus patients with Helicobacter pylori positive peptic ulcer
摘要
Abstract
Objective To study the clinical efficacy of quadruple therapy for type 2 diabetic mellitus (DM) patients with Helicobacter pylori (Hp) positive peptic ulcer.Methods A total of 176 patients with Hp-positive peptic ulcer were enrolled in the control group and 122 Hp-positive peptic ulcer patients with type 2 diabetes were involved in the treatment group.Both groups were treated with oral rabeprazole 10 mg qd + oral clarithromycin 0.25 g bid + oral amoxicillin 0.5 g bid + oral citrate bismuth potassium 0.3 g qid.Clarithromycin and amoxicillin were used for the first 10 days,the remaining drugs are taking 4 weeks.The clinical efficacy and the incidence of adverse drug reactions between the groups were compared,and the relationship between the type 2 diabetes and the eradication of Hp were analyzed.Results After treatment,the total effective rates of the treatment group and the control group were 86.06％ (105/122 cases) and 94.32％ (166/176 cases) respectively,with statistically significant difference (P ＜ 0.05).The eradication rates of Hp in the treatment group and the control group were 72.13％ (88/122 cases) and 86.93％ (153/176 cases) respectively,and the difference was statistically significant (P ＜0.05).Adverse reactions in the treatment group were nausea,diarrhea and melena;adverse effects in the control group were nausea,diarrhea and vomiting.The incidences of adverse drug reactions in the treatment group and the control group were 9.83％ (12/122 cases) and 10.23％ (18/176 cases),without statistically significant difference (P ＞0.05).Conclusion The clinical efficacy of the control group was better than that of the treatment group,indicating that type 2 diabetes should be considered as a key factor in the treatment of Hp positive peptic ulcer.关键词
四联疗法/幽门螺杆菌/2型糖尿病/消化性溃疡Key words
quadruple chemotherapy/Helicobacter pylori/type 2 diabetic mellitus/peptic ulcer分类
医药卫生引用本文复制引用
陈德清,何松,左的于,邱子津,杜小龙,左国庆..四联疗法治疗2型糖尿病合并幽门螺杆菌阳性消化性溃疡的临床研究[J].中国临床药理学杂志,2017,33(12):1091-1093,3.基金项目
国家自然科学基金资助项目(81271598) （81271598）
重庆市卫生局医学科研重点基金资助项目(2012-1-035) （2012-1-035）
