中国临床药理学杂志2017，Vol.33Issue(12)：1120-1122,1126,4.DOI:10.13699/j.cnki.1001-6821.2017.12.014
亮丙瑞林注射剂联合佳蓉片治疗子宫内膜异位症伴不孕的临床研究
Clinical trial of leuprolide injection combined with Jiarong tablets in the treatment of endometriosis associated with infertility
摘要
Abstract
Objective To observe the clinical efficacy and safety of leuprolide injection combined with Jiarong tablets in the treatment of endometriosis associated with infertility.Methods Sixty-eight patients of endometriosis with infertility were randomly divided into control group (n =34 cases) and treatment group (n =34 cases).Two groups were treated with laparoscopic surgery.Control groups was given leuprolide 3.75 mg,subcutaneous injection,at 1-2 days after menstruation,once four weeks for 6 times.Treatment group was given Jiarong tablets 0.92 mg tid oral for 15 days,on the basis of the control group.The clinical efficacy,follicule stimulating hormone (FHS),luteinizing hormone (LH),estradiol,testosterone,sex hormone binding globulin (SHBG),pregnancy rate and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 94.12％ (32/34 cases) and 76.47％ (26/34 cases),the pregnancy rates in treatment and control groups were 52.94％ (18/34 cases) and 26.47％ (9/34 cases),with significant difference (P ＜0.05).After treatment,the main indexes in treatment and control groups were compared:the FHS were (6.33±0.75),(8.31 ±0.99)U · L-1;LH were (5.39 ±0.59),(6.21 ±0.86)U · L-1;estradiol were (38.02 ±5.17),(68.39 ±7.47) pmol · L-1;testosterone were (0.81 ± 0.90),(1.14 ± 0.17) nmol · L-1;SHBG were(80.07 ±9.17),(56.54 ±7.07) nmol · L-1,with significant differenee(P ＜0.05).The adverse drug reactions in treatment group were based on sweating and reduced volume,which in control group was sweating,vaginal bleeding and lower abdominal pain.The incidences of adverse drug reactions in treatment and control groups were 8.82％ and 11.76％,without significant difference (P ＞ 0.05).Conclusion Leuprolide injection combined with Jiarong tablets has a definitive clinical efficacy in the treatment of endometriosis associated with infertility,without increasing the incidence of adverse drug reactions.关键词
亮丙瑞林注射剂/佳蓉片/子宫内膜异位症/不孕Key words
leuprorelin injection/Jiarong tablet/endometriosis/infertility分类
医药卫生引用本文复制引用
王霞,秦明丽,刘芳,张雪..亮丙瑞林注射剂联合佳蓉片治疗子宫内膜异位症伴不孕的临床研究[J].中国临床药理学杂志,2017,33(12):1120-1122,1126,4.基金项目
泸州市科学技术研究基金资助项目(泸市科函2012-12) （泸市科函2012-12）
