中国临床药理学杂志2017，Vol.33Issue(12)：1123-1126,4.DOI:10.13699/j.cnki.1001-6821.2017.12.015
利多卡因注射液联合罗哌卡因注射液对断指再植术的麻醉疗效
Anesthetic efficacy of lidocaine injection combined with ropivacaine injection in the treatment of digital replantation
摘要
Abstract
Objective To observe the anesthetic efficacy and safety of lidocaine injection combined with ropivacaine injection in the treatment of digital replantation.Methods Seventy-two patients underwent replantation were randomly divided into control group (n =36 cases) and treatment group(n =36 cases).Control group was given ropivacaine injection 10 mL with upper limb vein injection.Treatment group received lidocaine injection 10 mL with upper limb vein injection,on the basis of control group.The anesthetic effect,C reactive protein(CRP) and adverse drug reactions were compared between the two groups.Results The proportion of anesthesia effect of grade Ⅰ in treatment and control groups were 97.22％ (35/36 cases) and 83.33％ (30/36 cases) with significant difference(P ＜0.05).After operation 1,3 d,the levels of CRP in treatment group were(7.25 ± 1.07),(7.14 ± 0.96) mg · L-1,which in control group were(8.12 ± 1.18),(7.90 ± 1.01) mg · L-1 with significant difference (P ＜ 0.05).The main adverse drug reactions in treatment group were based on limb movement and skin flushing,which in control group were based on limb,skin flushing and skin itching.The incidences of adverse drug reactions in treatment and control groups were 5.56％ and 22.22％ with significant difference (P ＜ 0.05).Conclusion Lidocaine injection combined with ropivacaine injection has a definitive anesthetic efficacy and safety in the treatment of digital replantation.关键词
罗哌卡因注射液/利多卡因注射液/断指再植术/麻醉效果/安全性Key words
ropivacaine injection/lidocaine injection/digital replantation/anesthesia efficacy/safety分类
医药卫生引用本文复制引用
柯超群,黄志斌,汤昌明,林慧卿,吴寿和..利多卡因注射液联合罗哌卡因注射液对断指再植术的麻醉疗效[J].中国临床药理学杂志,2017,33(12):1123-1126,4.基金项目
佛山市医学类科技攻关基金资助项目(20151021030016) （20151021030016）
