中国输血杂志2017，Vol.30Issue(5)：501-503,3.DOI:10.13303/j.cjbt.issn.1004-549x.2017.05.018
外用人纤维蛋白粘合剂凝胶性能研究
Research on gelation ability of fibrin sealant
蒋桂香 1朱光祖 1罗观文 1胡川 1周燕莉 1殷如1
作者信息
- 1. 广东双林生物制药有限公司,广东湛江524000
- 折叠
摘要
Abstract
Objective To development and produce fibrin adhesive products.Gel performance indicators such as gel speed,duration,elasticity and tensile strength were studied.Methods Product was prepared by separation of ethanol precipitation,ion exchange chromatography and multiple virus inactivated process.Tensile test in mice were used to study in vitro on gel performance indicators.Results All performance indicators of fibrinogen and thrombin were superior to Chinese pharmacopoeia standards.The bonding time of the binder is within 2 s and gel with fast speed;the gel duration within 600-700 min at 37 ℃.Using bovine test solution,the fibrinogen dissolution decreased,while the duration of the gel was extended.The average per unit area stretching height for fibrin glue was 6.4-7.4 mm,the best tensile strength was 80 g/cm2,which was insufficient.Conclusion Human fibrin sealant products were developed with gel properties,such as increased strength,high elasticity,fast gel and long duration.关键词
纤维蛋白粘合剂/纤维蛋白原/人凝血酶/凝胶性能Key words
Fibrin sealant/fibrinogen/thrombin/gelation ability分类
医药卫生引用本文复制引用
蒋桂香,朱光祖,罗观文,胡川,周燕莉,殷如..外用人纤维蛋白粘合剂凝胶性能研究[J].中国输血杂志,2017,30(5):501-503,3.
