中国实用儿科杂志2017，Vol.32Issue(7)：487-491,5.DOI:10.19538/j.ek2017070603
原发性免疫缺陷病免疫功能评估进展
Progress of immune functional evaluation in primary immunodeficiency diseases
摘要
Abstract
Primary immune deficiency(PID) represents a highly heterogeneous group of disorders from early ages.The clinical manifestations of these diseases were mainly recurrent and severe infections.Because of the difficulty on diagnosis and differential diagnosis and on treatment of recurrent and refractory infections,most PIDs were intractable cases.Recent advance in the understanding of the inmune system have led to the development of novel immunologic assays to aid in the diagnosis of these disorders,and more and more PID patients are diagnosed and have received suitable therapy.In this article,the author reviewed the progress and application of immune functional evaluation in PID,including flow cytometry (FCM),investigating T cell receptor excision circles(TREC),T cell receptor beta-chain variable region (TCRBV) repertoire diversity.关键词
原发性免疫缺陷病/流式细胞术/T细胞受体删除环/T细胞受体多样性Key words
primary immunodeficiency disease/flow cytometry/T cell receptor excision circles/T cell receptor diversity分类
医药卫生引用本文复制引用
蒋利萍,向青青..原发性免疫缺陷病免疫功能评估进展[J].中国实用儿科杂志,2017,32(7):487-491,5.基金项目
国家卫生和计划生育委员会公益性行业科研专项(201402012) （201402012）
重庆市科学技术委员会社会事业与民生保障科技创新专项(cstc2015shmszx120028) （cstc2015shmszx120028）
