中国实用妇科与产科杂志2017，Vol.33Issue(7)：678-684,7.DOI:10.19538/j.fk2017070105
遗传性易栓症的妊娠期筛查与抗凝治疗评价
Evaluation of the screening and anticoagulation therapy for inherited thrombophilias in pregnancy
摘要
Abstract
In Han populations,deficiencies in protein S and protein C are most common,and deficiencies in antithrombin are not common,while F Ⅴ L mutation and PGM mutation are rare.Inherited thrombophilias increase the risk of gestational venous thromboembolism,and become a contributory factor rather than a single cause of such placentamediated pregnancy complications.If there are clear indications for treatment,there is no need for any inherited thrombophilias screening.Screening may be useful if the cause is unknown and the positive outcome of inherited antithrombotic screening may affect treatment decisions.The existing evidence suggests that prophylactic use of low-dose aspirin can reduce pre-eclampsia.Regarding the question whether LMWH can reduce the risk of recurrence of placenta-mediated pregnancy complications,the conclusions of single center and multi-center studies are different.Despite limited evidence of efficacy,it is recommended to use selective and personalized anticoagulant therapy to prevent these complications.关键词
遗传性易栓症/妊娠期/筛查/抗凝治疗Key words
inherited thrombophilias/pregnancy/screening/anticoagulation therapy分类
医药卫生引用本文复制引用
连岩,王谢桐..遗传性易栓症的妊娠期筛查与抗凝治疗评价[J].中国实用妇科与产科杂志,2017,33(7):678-684,7.基金项目
泰山学者工程专项经费国家自然科学基金(81571461) （81571461）
