中国现代医学杂志2017，Vol.27Issue(15)：11-14,4.DOI:10.3969/j.issn.1005-8982.2017.15.003
纳米碳酸钙驱铅效果研究
Therapeutic effect of calcium carbonate nanoparticle on lead poisoning
摘要
Abstract
Objective To evaluate the therapeutic effects of calcium carbonate nanoparticle. Methods Calcium carbonate nanoparticle with 40~80 nanometers was prepared by high gravity reaction precipitation. The severe level of lead-poisoning model (estimated blood lead concentration of 500μg/L or above) was made in 4 weeks old rats through 14 days consecutively drinking lead acetate solution. The drug efficacy was estimated by the concentration of blood lead. Results After three weeks of drug administration, the average concentration of blood lead in calcium carbonate nanoparticle group was (117 ± 7)μg/L, which was closed to the normal blood lead, and was lower than that of the untreated group ( <0.05). The mean level of blood lead concentration of untreated group was (297 ± 33)μg/L, which was a moderate lead poisoning level. Conclusions Calcium car-bonate nanoparticle with size from 40 to 80 nm displays high efficiency of lead-out effect and is better than natural lead removal.关键词
铅中毒/纳米碳酸钙/驱铅效果/自然排铅Key words
lead poisoning/nano calcium carbonate/flooding lead effect/natural lead removal分类
医药卫生引用本文复制引用
朱轩仪,黄彦凝,巫放明,潘一峰,何剪太,肖平..纳米碳酸钙驱铅效果研究[J].中国现代医学杂志,2017,27(15):11-14,4.基金项目
卫生部国际科技合作项目(No:2013DFA31440) （No:2013DFA31440）
