中国现代医学杂志2017，Vol.27Issue(15)：68-73,6.DOI:10.3969/j.issn.1005-8982.2017.15.014
血清IgG水平正常的系统性红斑狼疮临床特点
Clinical features of systemic lupus erythematosus with normal serum IgG levels
阳正波 1代思源 1戴艳玲 1付双双 1张卫茹 2宁建平1
作者信息
- 1. 中南大学湘雅医院 肾内科,湖南 长沙 410008
- 2. 中南大学湘雅医院风湿免疫科,湖南 长沙 410008
- 折叠
摘要
Abstract
Objective To investigate the clinical characteristics of systemic lupus erythematosus (SLE) with normal serum IgG levels. Methods A retrospective study of 259 newly diagnosed SLE patients was conducted to compare extrarenal clinical manifestations, renal manifestations, erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein (hs-CRP), immunological indexs and SLEDAI scores between normal serum IgG levels group and increased serum IgG levels group. The correlation of serum IgG levels to serum C3, serum C4 and SLEDAI scores was analyzed. The correlation of serum IgG levels to urinary protein and urinary IgG levels was analyzed too. Results Normal serum IgG levels group had lower incidences of non-infectious fever, alopecia, arthritis and anemia ( <0.05) while higher incidences of thrombocytopenia ( <0.05). Incidences of lupus nephritis were similar between the two groups. However, normal serum IgG levels group had higher levels of urinary protein and urinary IgG ( <0.05), except higher incidences of nephrotic proteinuria and hematuria ( <0.05). The levels of urinary protein and urinary IgG were negative correlated with serum IgG levels ( <0.05). The levels of ESR and hs-CRP in Normal serum IgG levels group were lower than those in increased serum IgG levels group ( <0.01). Normal serum IgG levels group had lower levels of serum IgG, IgA and IgM ( <0.01), except lower positive rate of ANA, dsDNA, Sm and AnuA ( <0.05). There was no significant difference in the serum C3 levels, the incidences of decreased serum C3 level and the SLEDAI scores between the two groups ( <0.05). Serum IgG levels was not correlated with serum C3, serum C4 and SLEDAI scores ( <0.05). Conclusions The active SLE patients with normal serum IgG levels is not rare. In these patients, the renal damage is more obvious relatively and the positive rate of the SLE-related autoantibody is lower than the SLE patients who have high serum IgG levels. The serum IgG levels is not correlated with the lupus disease activity.关键词
系统性红斑狼疮/血清免疫球蛋白G水平正常/临床特点Key words
systemic lupus erythematosus/normal serum immunoglobulin G level/clinical feature分类
医药卫生引用本文复制引用
阳正波,代思源,戴艳玲,付双双,张卫茹,宁建平..血清IgG水平正常的系统性红斑狼疮临床特点[J].中国现代医学杂志,2017,27(15):68-73,6.
