中国现代医学杂志2017，Vol.27Issue(16)：40-43,4.DOI:10.3969/j.issn.1005-8982.2017.16.008
胃癌中高表达的CBX7对细胞迁移、侵袭的影响
CBX7 expression in human gastric cancer and its role in cell migration and invasion
宗华 1秦杰 1李红春 1朱立元1
作者信息
- 1. 广东省深圳市第三人民医院 普外科,广东 深圳 518000
- 折叠
摘要
Abstract
Objective To study the expression of chromobox homolog 7 (CBX7) in human gastric carcinoma and its role in cell migration and invasion. Methods Immunohistochemical method was applied to detect the expression of CBX7 in gastric cancer and matched tumor-adjacent tissues of 45 patients. The correlations between CBX7 expression and clinical features were analyzed by Pearson chi-square test. Recombinant CBX7 plasmid was used to over-express CBX7 in SGC-7901 cells. The effect of CBX7 on cell migration and invasion was measured by Transwell assay. Results The expression of CBX7 was significantly down-regulated in the gastric cancer tissues, and the low expression of CBX7 was associated with lymphatic metastasis and advanced TNM stage (stageⅢ and Ⅳ) ( < 0.05). Over-expression of CBX7 inhibited the migration and invasion of SGC-7901 cells ( < 0.05). Conclusions CBX7 expression is decreased in gastric cancer tissues. Up-regulation of CBX7 expression could play an anti-cancer role through inhibition of cell migration and invasion.关键词
CBX7/胃癌/迁移/侵袭Key words
CBX7/gastric cancer/migration/invasion分类
医药卫生引用本文复制引用
宗华,秦杰,李红春,朱立元..胃癌中高表达的CBX7对细胞迁移、侵袭的影响[J].中国现代医学杂志,2017,27(16):40-43,4.
