中国现代医学杂志2017，Vol.27Issue(16)：44-48,5.DOI:10.3969/j.issn.1005-8982.2017.16.009
血清胎球蛋白A水平与胰岛素抵抗及颈动脉内膜中 层厚度在初诊2型糖尿病患者中的相关性分析
Association of fetuin-A level with insulin resistance and carotid intima-media thickness in patients with newly-diagnosed type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the correlations of fetuin-A (FA) level with insulin resistance (IR) and carotid intima-media thickness (CIMT) in patients with newly-diagnosed type 2 diabetes mellitus (nT2DM). Methods One hundred cases of nT2DM patients were selected as experimental group (T2DM group) while 100 people with normal glucose tolerance (NGT) as control group (NGT group). Serum FA level was measured by a commercial solid-phase ELISA kit. The estimation of IR was calculated by homeostasis model assessment (HOMA-IR). CIMT was measured by color B-mode ultrasound. The correlations of serum fetuin-A level with the metabolic parameters were also analyzed. Results The serum FA level in the T2DM group was significantly higher than that in the NGT group [(368.5 ± 15.6) vs (152.7 ± 7.1) mg/ml, =0.000]. Serum FA level was positively correlated with HOMA-IR ( =0.483, =0.000), CIMT ( =0.509, =0.000), glycated hemoglobin ( =0.153, =0.042), triglyceride ( =0.353,= 0.000), low-density lipoprotein cholesterol ( = 0.113, = 0.023), body mass index ( = 0.162, = 0.024), systolic blood pressure ( = 0.182, = 0.035), fasting plasma glucose ( = 0.422, = 0.002) and 2-h post-glucose load blood glucose ( = 0.581, = 0.000); but negatively correlated with fasting plasma insulin ( = -0.153, =0.008), 2-h plasma insulin after glucose load ( =-0.423, =0.008), high-density lipoprotein cholesterol ( =-0.183,=0.011) and HOMA-β-cell insulin secretion index ( =-0.463, =0.000). Conclusions The study demonstrated that serum FA level is correlated with IR and CIMT in patients with nT2DM. Therefore, serum FA level can be used as an independent marker in the diagnosis of macroangiopathies in patients with nT2DM.关键词
初诊2型糖尿病/胎球蛋白A/胰岛素抵抗/颈动脉内膜中层厚度Key words
newly-diagnosed type 2 diabetes mellitus/fetuin-A/insulin resistance/carotid intima-media thickness分类
医药卫生引用本文复制引用
党玉婷,尹亮,孙侃,常向云..血清胎球蛋白A水平与胰岛素抵抗及颈动脉内膜中 层厚度在初诊2型糖尿病患者中的相关性分析[J].中国现代医学杂志,2017,27(16):44-48,5.基金项目
国家自然科学基金地区基金项目(No:81560137 （）
No:81560139) （）
