中国现代医学杂志2017，Vol.27Issue(16)：49-52,4.DOI:10.3969/j.issn.1005-8982.2017.16.010
年轻患者子宫内膜癌组织中ER、PR、P53 病理表达情况及其临床意义
Expressions of ER, PR and p53 in young patients with endometrial carcinoma and clinical significance
摘要
Abstract
Objective To retrospectively analyze the clinical data of endometrial cancer in young patients, and study the expressions of ER, PR and p53 in the cancer tissues, in the order to know the clinical significance. Methods A total of 424 cases of endometrial carcinoma were divided into two groups by age of 45 years. Their clinical and pathological data were retrospectively analyzed, and the incidence of endometrial cancer in the young patients and prognostic factors were studied. Results There were significant differences in the gravidity and parity history, the presence of complications or not, the histological grade, the depth of myometrial invasion and the positive rates of PR and p53 between the patients ≥45 years of age and those <45 years of age ( < 0.05). In the endometrial cancer patients <45 years of age, ER and PR expressions were negatively correlated with age; p53 expression was positively correlated with histological grade ( =0.289, <0.05) but negatively correlated with depth of myometrial invasion ( =-0.345, <0.05). Conclusions Endometrial cancer monitoring and health management should be strengthened in young patients with endometrial cancer. Higher expressions of ER and PR in young patients with endometrial carcinoma provide evidence for the feasibility of hormone therapy. In young patients with endometrial cancer, p53 expression is low; positive expression of p53 is correlated with histological grade and depth of myometrial invasion, therefore, p53 can be used as an index of prognosis.关键词
子宫内膜癌/高危因素/雌激素受体/孕激素受体/P53Key words
young endometrial carcinoma/high risk factor/estrogen receptor/progestrone receptor/p53分类
医药卫生引用本文复制引用
宋扬,廖予妹..年轻患者子宫内膜癌组织中ER、PR、P53 病理表达情况及其临床意义[J].中国现代医学杂志,2017,27(16):49-52,4.基金项目
河南省基础与前沿技术研究计划项目(No:122300410409) （No:122300410409）
