中国畜牧兽医2017，Vol.44Issue(6)：1613-1620,8.DOI:10.16431/j.cnki.1671-7236.2017.06.006
细菌多糖的生物合成机制研究进展
Advances on the Biosynthesis Mechanism of Bacterial Polysaccharides
摘要
Abstract
Polysaccharide is the major component of bacterial cell that plays a significant role in the interaction between bacteria and their hosts.It aids the identification of bacteria, imparting virulence to the bacteria and adjusting host's immune response as well.Advance genomics research has deciphered several different bacterial polysaccharides sharing a common biosynthesis mechanism.The study of polysaccharides is mainly based on sequence analysis and prediction of genome in combination with metabolite analyses that still requires a detailed study.Researchers are now further focusing on their biosynthetic pathways to unveil the mechanisms underlying the diversity of these bacterial polysaccharides along with the host-pathogen interaction.It will open new doors for vaccine development and other therapeutic methods against pathogenic bacteria, and also provide technical support to control disease and cure at molecular level.This review states the mechanisms and relevant problems of biosynthesis and in vitro biosynthesis of peptidoglycan,O-antigen and capsular polysaccharides,and summarizes the application of bacteria polysaccharides in the aspects of searching for candidate antigens and controlling the targets of pathogenic bacteria and exploring genetic evolution of bacteria and biological synthesis.关键词
细菌多糖/生物合成/机制Key words
bacterial polysaccharides/biosynthesis/mechanism分类
生物科学引用本文复制引用
王浩,卢天成,王岩,王秀然..细菌多糖的生物合成机制研究进展[J].中国畜牧兽医,2017,44(6):1613-1620,8.基金项目
国家自然科学基金"寡糖修饰对布鲁氏菌抗原蛋白rRS-α免疫原性影响的研究"(31302062) （31302062）
