中国畜牧兽医2017，Vol.44Issue(6)：1854-1860,7.DOI:10.16431/j.cnki.1671-7236.2017.06.039
氟苯尼考-羟丙基-β-环糊精包合物的研制
Preparation and Identification of Florfenicol-hydroxypropyl-β-cyclodextrin
摘要
Abstract
Florfenicol-hydroxypropyl-β-cyclodextrin was prepared by colloid mill technique using orthogonal experiment technology to improve its solubility.The inclusion rate and getting ratio of the complex were taken as indexes to analyze the effect.The optimum preparation procedure was the proportion of 1∶1 for HP-β-CD to florfenicol, the concentration was 6 mg/mL and the time was 1 h.Its structure was proved by DSC and IR, which suggested that the florfenicol was wrapped by HP-β-CD.The inclusion rate was 83.74% and the getting ratio was 98.48%.The solubility of florfenicol was increased from 1.25 mg/mL to 40.76 mg/mL.Thus, it showed that the process was suitable for batch preparation of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex.关键词
氟苯尼考/羟丙基-β-环糊精/包合物/溶解度/正交设计Key words
florfenicol/hydroxypropyl-β-cyclodextrin/inclusion complex/solubility/orthogonal experiment分类
农业科技引用本文复制引用
杨宝亭,王庚南,黄康东,刘静,刘聚祥..氟苯尼考-羟丙基-β-环糊精包合物的研制[J].中国畜牧兽医,2017,44(6):1854-1860,7.基金项目
河北省现代农业产业技术体系蛋鸡产业创新团队项目 （）
石家庄市科技局项目(141490772A) （141490772A）
