摘要
Abstract
ObjectiveTo evaluate the efficacy and safety of high-flow nasal Cannulae (HFNC) oxygen therapy in premature infants.ethodsRCT studies were identified by a systematic search in Medline, the Cochrane Library, Web of Science, Embase, Chinese Knowledge Network, VIP, CBM and Wanfang database, from its establishment to March 31, 2017.The primary outcome was hospital mortality and the incidence of mechanical ventilation (tracheal intubation).The secondary outcome included BPD, air leakage, pulmonary infection, nasal trauma,and application of pulmonary surfactant.ResultsEight articles were included in the meta-analysis, and 1 604 children were included, including 799 cases in HFNC group, 805 cases in NCPAP group.8 articles were reported in the random sequence of the computer, 7 mentioned the use of the allocation of hidden, 8 papers were lost, data integrity was good, the results of the reports were not selective, other bias was not clear.There was no significant difference in mortality and intubation rate between the two groups.The tracheal intubation rate of NCPAP was lower than HFNC group in children with mean weight ≥1 500 g(OR=1.58,95%CI:1.11~2.26,P=0.01)and gestational age more than 28 weeks(OR=1.58,95%CI:1.13~2.22,P=0.008).There was no significant difference in the incidences of BPD, air leakage and pulmonary infection and the rate of pulmonary surfactant application between the two groups.The incidence of nasal trauma HFNC group was lower than that of NCPAP (OR=-0.14,95%CI:-0.19~-0.09,P<0.0001).ConclusionThe efficacy and safety of HFNC in premature infants should be further confirmed, but it has obvious advantages in reducing the incidence of nasal injury关键词
经鼻高流量氧疗/经鼻持续气道正压通气/早产儿/Meta分析Key words
High-flow nasal cannulae/Nasal continuous positive airway pressure/Premature infants/Meta-analysis
