中国药科大学学报2017，Vol.48Issue(2)：125-134,10.DOI:10.11665/j.issn.1000-5048.20170201
抗糖尿病小分子ABHD6抑制剂的研究进展
Advances in antidiabetic small molecule ABHD6 inhibitors
司良辉 1马惠 1周金培 1张惠斌1
作者信息
- 1. 中国药科大学新药研究中心,南京210009
- 折叠
摘要
Abstract
Type 2 diabetes,a glucose and lipid metabolism disorder accompanied by chronic multiple organ damage,has become a huge threat to human health,α/β hydrolase domain-6 (ABHD6) regulates the insulin release negatively by hydrolyzing monoacylglycerol.Small molecule ABHD6 inhibitors have been proven to lower bloodglucose and regulates energy homeostasis,which is a potential candidate for the treatment of type 2 diabetes.This paper introduced the ABHD6 signaling pathway and its mechanism,then reviewed the progress of small molecule ABHD6 inhibitors with different structures in recent years,and analyzed the structure activity relationship.关键词
糖脂代谢/α/β水解酶结构域-6/ABHD6抑制剂/抗糖尿病药/进展Key words
glucose and lipid metabolism/α/β hydrolase domain-6/ABHD6 inhibitors/antidiabetic drugs/advances分类
医药卫生引用本文复制引用
司良辉,马惠,周金培,张惠斌..抗糖尿病小分子ABHD6抑制剂的研究进展[J].中国药科大学学报,2017,48(2):125-134,10.
