中国药科大学学报2017，Vol.48Issue(2)：233-241,9.DOI:10.11665/j.issn.1000-5048.20170216
抗肿瘤新靶点CDK9及其抑制剂的研究进展
Advances in research on a novel antitumor target CDK9 and its inhibitors
陈明 1谢周令 1李听寒 1韦志辉 1赵璐 1李志裕1
作者信息
摘要
Abstract
The cyclin-dependent protein kinase 9 (CDK9) is a member of the family of cyclin-dependent protein kinases.Different from other CDKs,CDK9 mainly works on the transcription regulation and has no affects on the cell cycle progress.There are many kinds of CDK9 inhibitors in the clinical research.The detailed structure and action mechanism of CDK9,its difference of protein structure from other CDKs,several selective or nonselective CDK9 inhibitors,as well as their structure-activity relationship (SAR) are discussed in this paper.关键词
CDK9/转录调控/CDK9抑制剂/抗肿瘤/靶点/构效关系/进展Key words
CDK9/transcriptional regulation/CDK9 inhibitors/antitumor targets/SAR/advances分类
医药卫生引用本文复制引用
陈明,谢周令,李听寒,韦志辉,赵璐,李志裕..抗肿瘤新靶点CDK9及其抑制剂的研究进展[J].中国药科大学学报,2017,48(2):233-241,9.
