中国药房2017，Vol.28Issue(19)：2631-2634,4.DOI:10.6039/j.issn.1001-0408.2017.19.11
高良姜素的体外透皮吸收特性研究
Study on the in vitro Transdermal Absorption Properties of Galangin
摘要
Abstract
OBJECTIVE:To investigate the in vitro transdermal absorption properties of galangin and effects of different pene-tration enhancers on its transdermal behaviors,and provide reference for developing skin preparations using galangin as APIs in the treatment of vitiligo. METHODS:HPLC was used to determine the galangin content. Using cumulative permeation rate (Q) and the transdermal rate(J)of galangin as indexes,the effect of absorption of receiving solution [20%,40% polyethylene glycol 400 (PEG400)solution and 30% ethanol solution] and rotating rate(200,300,400 r/min)on galangin in complete skin of mice were investigated,as well as the azone(1%,3%,5%)and propylene glycol(10%,20%,40%)alone or combination on its penetra-tion promotion. And the transdermal properties of galangin in complete skin,exfoliating skin,dermis skin of rats and mice were de-tected. RESULTS:The best permeability of complete skin of mice showed in 40% PEG400 solution at rotating speed of 300 r/min with 5% azone alone,J was 3.2570 μg/(cm2·h). Js of complete skin,exfoliating skin,dermis skin of mice were 2.7199,34.016, 33.874 μg/(cm2·h),respectively;and those of rats were 0.4996,9.5124,17.406 μg/(cm2·h). CONCLUSIONS:Galangin can penetrate the complete skin of mice and rats,however,the penetration quantity is far lower than exfoliating skin and dermis skin.关键词
高良姜素/透皮吸收/促透剂/完整皮肤/去角质层皮肤/真皮层皮肤Key words
Galangin/Transdermal absorption/Transdermal enhancer/Complete skin/Exfoliating skin/Dermis skin分类
医药卫生引用本文复制引用
霍仕霞,高莉,彭晓明,温季轩,闫明..高良姜素的体外透皮吸收特性研究[J].中国药房,2017,28(19):2631-2634,4.基金项目
新疆地产中药民族药新药研发培育项目(No. Q2015-02-3) （No. Q2015-02-3）
新疆维吾尔自治区科技人才培养项目(No.qn2015yx042) （No.qn2015yx042）
