中国药房2017，Vol.28Issue(20)：2764-2767,4.DOI:10.6039/j.issn.1001-0408.2017.20.08
注射用亚叶酸钙与葡萄糖注射液、氯化钠注射液的配伍稳定性考察
Study on Compatible Stability of Calcium Folinate for Injection Mixed with Glucose Injection and Sodium Chloride Injection
摘要
Abstract
OBJECTIVE:To investigate the compatible stability of Calcium folinate for injection mixed with Glucose injection and Sodium chloride injection. METHODS:Referring to clinical common concentration,each 3 Calcium folinate for injection (each injection was equal to calcium folinate 100 mg)were respectively mixed with Glucose injection 250 mL or Sodium chloride injection 250 mL. At room temperature,under light or dark condition,the appearance of mixtures,pH value and the number of in-soluble particles were investigated 0,1,2,3,4,6,8,12,24,36,48 h. The contents of calcium folinate in mixtures were deter-mined by HPLC. RESULTS:Under above condition,the color of the mixtures had no change,and no gas,precipitation and turbid-ity was found;there was no evident change in pH values(RSD<2%,n=11). 0 h after mixing,there was large number of parti-cles≥10 μm in mixtures,but the number of particle was decreased as time;within 48 h,the number of particles ≥10 μm and ≥25 μm in mixtures were all in line with the standard of Chinese Pharmacopeia(2015 edition). Under the protection from light con-dition,relative contents of calcium folinate in mixtures had no significant change(RSD<2%,n=11). Under light condition,rela-tive contents of calcium folinate in mixtures decreased significantly,decreasing to 94.5%(mixed with Glucose injection) and 88.4%(mixed with Sodium chloride injection). CONCLUSIONS:Calcium folinate for injection is more stable in Glucose injec-tion,and the stability of compatibility can be affected by light conditions. After mixed with Glucose injection and Sodium chloride injection,Calcium folinate for injection should be kept away from light and used as soon as possible关键词
注射用亚叶酸钙/葡萄糖注射液/氯化钠注射液/配伍稳定性Key words
Calcium folinate for injection/Glucose injection/Sodium chloride injection/Compatible stability分类
医药卫生引用本文复制引用
安静,李婵艺,李倩,白万军,董占军..注射用亚叶酸钙与葡萄糖注射液、氯化钠注射液的配伍稳定性考察[J].中国药房,2017,28(20):2764-2767,4.基金项目
河北省医学科学研究重点课题计划(No.20160062) （No.20160062）
河北省政府资助临床医学优秀人才培养项目(No.361003) （No.361003）
